Q. Which is the first step involved in chymotrypsin mediated peptide bond hydrolysis?

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Q. Which of this is not true for the active site of an enzyme?

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Q. Daniel Koshland proposed a model for enzyme’s reaction mechanism in 1958 which is termed as __________

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Q. In lock and key model, the enzyme catalyzed reaction may produce an adverse reaction.

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Q. The energy required to attain transition state is referred to as _____________

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Q. The transition state cannot be achieved by using one of the following methods?

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Q. Which of the following factor has a negative impact on substrate collision theory?

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Q. The type of catalysis wherein the proton donation or acceptance is done by water molecule is referred to as _____________

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Q. In the catalysis of RNA by Bovine pancreatic RNase A, His 12 acts as proton donor.

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Q. The phenomenon which involves formation of an additional covalent intermediate in a reaction that helps to reduce the energy of later transition states is referred to as ___________

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Q. Chymotrypsin: Nucleophilic catalysis:: Carboxypeptidase A: __________

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Q. A type of catalysis which involves covalent intermediate transition state formation between the cationic electrophilic group in the enzyme and the electron rich portion of the substrate is referred to as ____________

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Q. _____________ involves donation of electrons from nucleophilic active site residues to a substrate forming a covalent adduct transition state intermediate.

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Q. Which of these is not required for electrophilic catalysis?

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Q. Which of the following assumption was not made in rapid equilibrium model?

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Q. Which of these is referred to as Kcat?

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Q. What does the following equation represent?

\(\frac{1}{V_0} = \frac{K_m}{V_{max}} \frac{1}{[S]}+\frac{1}{V_{max}}\)

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Q. Which of the following is based on rearrangement of Lineweaver Burk plot equation by multiplication of [S₀] factor?

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Q. Miachelis Menten model is also referred to as “rapid equilibrium model”.

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Q. ___________ is defined as the enzyme’s binding efficiency with its appropriate substrate through optimized multiple non-covalent interactions.

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