Q. Acids in the pKa range 2.5-7.5 are greatly affected by changes in pH making their absorption pH dependent.

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Q. Which one of these is an example of a strong acid drug?

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Q. Which one of these is not an example of a basic drug with pKa range 5-11?

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Q. Example of a drug which has PKa > 11 is ________

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Q. What should be the range of oil/water partition coefficient of any drug?

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Q. Ibuprofen a weak acid, in the stomach will be present in which of the given form?

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Q. Nitrazepam a weak base, will be in which form in the stomach?

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Q. All drugs which are weak acids or acidic in nature will be in a unionized form in the plasma.

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Q. Heroin with pKa 7.8 will be in which form in intestinal pH?

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Q. Which one of these options is not one of the limitations of pH-partition theory?

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Q. A microclimate pH, different from the luminal pH exists at the membrane surface.

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Q. According to the pH-partition theory which form of the drug gets absorbed mostly?

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Q. What helps the ionized drug molecules to pass through the cell membrane passively?

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Q. Acidic drugs are best absorbed through the stomach and basic drugs are best absorbed through the intestine.

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Q. What could be the reason that irrespective of pH any drug gets absorbed mostly from the intestine?

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Q. Drug having a small partition coefficient can rapidly penetrate the lipid membrane but diffusion through the unstirred water layer is a rate-limiting step.

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Q. What are the major stability problems which result in poor bioavailability of any orally administered drugs?

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Q. Which form of drug formulation has disintegration time?

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Q. Which tablets have longer Disintegration time?

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Q. Disintegration time is directly proportional to the amount of binder present in the tablet.

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