Question

Which of the following creates nonlinearity in drug distribution and not in drug absorption?

a.

When absorption is solubility or dissolution rate-limited

b.

When absorption involves carrier-mediated transport systems

c.

When a presystemic gut wall or hepatic metabolism attains saturation

d.

Saturation of binding sites on plasma proteins

Posted under Drug and Pharmaceutical Biotechnology

Answer: (d).Saturation of binding sites on plasma proteins

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Q. Which of the following creates nonlinearity in drug distribution and not in drug absorption?
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