Q. Formation of the active site only in the C complex is a necessity for avoiding wrong splicing.

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Q. Rearrange the order of the steps in the splicing mechanism.

i) Transesterification of 3’ splice site
ii) Formation of lariat complex
iii) Formation of active site
iv) Release of snRNPs

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Q. Group II introns are spliced by the splicosome complex.

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Q. The branch point site conserved sequence for group II intron is ___________

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Q. Which of the following groups can perform self splicing?

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Q. Self-splicing is achieved by the formation of specific structures within the introns.

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Q. How many types of specific domains are present in the SR protein?

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Q. Which of the following components of the splicosome machinery is recruited by the SR protein?

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Q. SR proteins are not essential for RNA splicing.

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Q. The presence and activity of SR determines the ___________

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Q. Alternative splicing is regulated by activators and repressors.

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Q. The Drosophila half-pint protein is _____________

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Q. Most silencer proteins are able to bind to pre-mRNA but cannot recruit the splicing machinery.

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Q. hrRNPA1 acts as the repressor for the final mRNA form of ____________

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Q. The pre-mRNA binding minor splicosome is also known as ___________

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Q. hnRNPI binds to which segment of the mRNA?

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Q. Alternative splicing of the Troponin T gene produces ____________ alternative forms of mRNA.

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Q. Which of the following mRNA is an example of having an extended exon?

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Q. Alternative splicing is always used to produce multiple isoforms of proteins.

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Q. Alternative splicing can be used to switch off a gene’s expression. How many ways are there to achieve it?

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