Q. The mutation occurs at a random basis within a genome.

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Q. What is the dinucleotide sequence of microsatellites?

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Q. By which process miss-incorporated base can change into a permanent mutation?

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Q. Detection of mismatches and fidelity of replication is maintained by mutation repair system.

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Q. How many steps are required to attain mismatch repair?

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Q. In E. coli mismatches are detected by which repair protein?

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Q. Mut S recruits how many component(s) to the mismatched site?

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Q. The nicking of DNA is followed by the adherence of a helicase known as __________

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Q. Mismatch repair system is ATP dependent.

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Q. By which enzyme does E. coli tags its parental DNA strand?

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Q. If the Mut H cuts the DNA at the 5’ side of the mismatch then which nuclease is activated?

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Q. What are the eukaryotic components of Mut S and Mut L of E. coli?

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Q. High level of mutation in the germ cells is acceptable but in somatic cells can be catastrophic.

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Q. Which base undergoes spontaneous damage under physiological conditions?

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Q. With which base uracil pairs in the opposite strand upon replication?

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Q. Which base is generated due to the deamination of adenine?

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Q. Which base is generated by the deamination of guanine?

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Q. Bases in the mRNA undergo depurination.

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Q. In vertebrate DNA, which base is frequently present in place of cytosine on which methyl transferase acts?

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Q. Which base is generated by the deamination of 5-methylcytosine?

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