Q. In pericentric inversion, the inversion loop involves __________ strands.

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Q. Which of the following case of duplication involves more than one chromosome?

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Q. Tandem duplication creates ____________ and reverse tandem creates_____________

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Q. The Streisinger’s model explains__________

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Q. If there are two sequences CGCGCGCG and ATATATAT, which will have a higher probability of being duplicated?

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Q. Which of the following will have the highest number of eye facete?

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Q. Duplication of Vermillion eye colour gene leads to the expression of the mutant phenotype. Which of the following can lead to normal phenotype with this duplication present?

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Q. Which human chromosomes are involved in Down’s syndrome?

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Q. Which of the following could be due to duplication?

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Q. If a gene undergoes duplication and one of the duplicated copy is mutated to render unexpressed protein. What will be the effect on phenotype?

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Q. During Strisinger’s model, what happens?

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Q. Deletion in sex chromosome is better tolerated than that in autosome.

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Q. How will you recognize a terminal deletion from breakage and loss at the terminal end?

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Q. What will be the effect of the deletion mutation of a gene at the telomere?

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Q. You hybridize two cells one of which carries a deletion mutation on chromosome 1. What will you expect to observe?

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Q. Which of the following is not a possible cause of lethality of individuals carrying a deletion mutation?

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Q. The appearance of a recessive phenotype due to deletion of dominant gene is called_______________

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Q. You generate a fluorescent probe against a gene that has been deleted. You expose the DNA to the probe and observe it under fluorescent microscope. What will you see?

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Q. Deletions in chromosomes give the following data-

Region of deletion Gene A activity

A1 +++

A2 ++

A3 +

A4 +++

A5 +++

Where is the gene located?

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Q. Deletion of a region led to over expression of a gene X. What do you conclude from this observation?

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