Question

Which of the following can explain anticipation?

a.

Due to slippage of the trinucleotide repeats we will see gradually all the repeat number increases as does the defective phenotype

b.

The child always expresses the phenotype more severely than unaffected parent

c.

The number of repeat beyond a particular threshold leads to improper replication

d.

It is inherited like linkage

Posted under Cytogenetics

Answer: (c).The number of repeat beyond a particular threshold leads to improper replication

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Q. Which of the following can explain anticipation?

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