Question

X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

a.

activation of B cells by T-independent antigens

b.

failure of B cells to provide co-stimulation for Th2 activation

c.

failure of Th2 cells to provide co-stimulation for B cell isotype switching

d.

failure of Th2 cells to provide co-stimulation for B cell proliferation

Posted under Biochemistry

Answer: (c).failure of Th2 cells to provide co-stimulation for B cell isotype switching

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Q. X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be...
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