Q. Movement of the replication fork generates ________________ in the unreplicated portion of DNA.

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Q. Which enzyme removes the positive supercoils generated when the replication fork?

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Q. When was DNA polymerase III discovered as the major enzyme behind DNA replication in bacteria?

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Q. How many copies (approximately) of DNA polymerase III are present in a typical bacterial cell?

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Q. The lagging strand is synthesized discontinuously.

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Q. Who made the discovery that one DNA strand is synthesized discontinuously in fragments?

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Q. Which enzyme joins the Okazaki fragments into a continuous strand?

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Q. Which of the following enzyme is responsible for initiating DNA replication?

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Q. Mutations in the DNA may be passed to the next generation.

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Q. How many pathways of nucleotide excision repair exist?

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Q. Which repair system operates to remove the altered bases generated by reactive chemicals present in the diet?

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Q. Which repair system operates to repair DNA strands that are actively transcribed?

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Q. A mismatched base pair can cause ________________ in the double helix.

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Q. Which of the following does not introduce double-strand breaks in the DNA?

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Q. The NHEJ pathway is used to rectify __________________ in the DNA.

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Q. Xeroderma pigmentosum is caused by ______________________

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Q. How many types of skin cancers can develop by overexposure to ultraviolet rays?

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Q. Which form of Xeroderma pigmentosum is observed in patients who cannot synthesize functional polymerase Η?

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Q. Replicative polymerase Η belongs to a family of polymerases involved in ________________

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Q. Which if the following polymerases have an unusually spacious active site?

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