Q. The scoring function for multiple sequence alignment is based on the concept of sum of pairs (SP).

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Q. Which of the following scores are not considered while calculating the SP scores?

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Q. Given a multiple alignment of three sequences, the sum of scores is calculated as the sum of the dissimilarity scores of every pair of sequences at each position.

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Q. There are two approaches viz. exhaustive and heuristic approaches used in multiple sequence alignment.

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Q. In a multidimensional search matrix, for aligning N sequences, an (N+2)-dimensional matrix is needed to be filled with alignment scores.

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Q. As the amount of computational time and memory space required increases exponentially with the number of sequences, it makes the multidimensional search matrix method computationally prohibitive to use for a large data set.

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Q. Which of the following is untrue about DCA?

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Q. Which of the following is untrue regarding the Progressive Alignment Method?

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Q. Clustal is a progressive multiple alignment program available either as a stand-alone or on-line program.

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Q. Which of the following is untrue regarding the progressive alignment method?

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Q. Which of the following is not a drawback of the progressive alignment method?

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Q. Which of the following is untrue regarding T-Coffee?

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Q. Which of the following is untrue about iterative approach?

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Q. Which of the following is untrue about PRRN?

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Q. The major drawback of the progressive and iterative alignment strategies is that they are largely global alignment based and may therefore fail to recognize conserved domains and motifs among highly divergent sequences of varying lengths.

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Q. Which of the following is untrue about DIALIGN2?

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Q. Match-Box compares segments of some of the nine residues of possible Pair wise alignments.

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Q. Which of the following is not the objective to perform sequence comparison?

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Q. A dotplot is a visual and qualitative technique whereas the sequence alignment is an exact and quantitative measure of similarity of alignments.

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Q. The global sequence alignment is suitable when the two sequences are of dissimilar length, with a negligible degree of similarity throughout.

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