Q. Which of the following is not a form of RNA?

View solution

Q. Unlike DNA, which is mainly double stranded, RNA is double stranded, although an RNA molecule can self-hybridize at certain regions to form partial double-stranded structures.

View solution

Q. Structures are not much important when it comes to the study of the functions.

View solution

Q. Which of the following is not a base of RNA?

View solution

Q. Base pairing, in RNA, is A–G and U–C.

View solution

Q. In addition to the canonical base pairing, there often exists non-canonical base pairing such as _________ and ________ base paring.

View solution

Q. Four main subtypes of secondary structures can be identified. They are hairpin loops, bulge loops, interior loops, and multi-branch loops.

View solution

Q. The ______ refers to a structure with two ends of a single-stranded region (loop) connecting a base-paired region (stem).

View solution

Q. The __________ refers to two single-stranded regions on opposite strands connecting two adjacent base-paired segments.

View solution

Q. At present, there are essentially two types of method of RNA structure prediction. One is the minimum free energy approach and the Second one is a comparative approach.

View solution

Q. Ab initio approach makes structural predictions based on ______

View solution

Q. In ab initio approach, generally, when a base pairing is formed, the energy of the molecule is _________ because of attractive interactions between the two strands.

View solution

Q. In ab initio methods, free energy can be calculated based on parameters empirically derived for small molecules.

View solution

Q. The energy necessary to form individual base pairs is not quite affected by adjacent base pairs.

View solution

Q. The attractive interactions lead to _________ energy.

View solution

Q. If the base pair is adjacent to loops or bulges, the neighboring loops and bulges tend to ___________ the base-pair formation.

View solution

Q. The scoring scheme based on the combined stabilizing and destabilizing interactions forms the foundation of the ab initio RNA secondary structure prediction method.

View solution

Q. Ab initio methods are energetically least favorable.

View solution

Q. The dot matrix method and the dynamic programming method can be used in detecting self-complementary regions of a sequence.

View solution

Q. In dot matrix in ab initio methods, the diagonals _____________ to the main diagonal represent regions that can self hybridize.

View solution