Q. In comparative approach to RNA structure prediction, algorithms that do not use pre-alignment, align multiple input sequences and infers a consensus structure.

View solution

Q. In comparative approach to RNA structure prediction, Foldalign is a web-based only program for RNA alignment

View solution

Q. In comparative approach to RNA structure prediction, the Foldalign program doesn’t use the covariation information.

View solution

Q. In comparative approach to RNA structure prediction, Dynalign is a ________ program.

View solution

Q. In comparative approach to RNA structure prediction, in Dynalign program–by comparing _________ from each sequence, a ______ structure common to both sequences is selected that serves as the basis for sequence alignment.

View solution

Q. Which of the following is incorrect about the RNA structure prediction?

View solution

Q. A type of RNA secondary structure prediction method takes into account conserved patterns of base-pairing that are conserved during evolution of a given class of RNA molecules.

View solution

Q. RNA secondary structure is composed primarily of triple-stranded RNA regions formed by folding the single-stranded molecule back twice on itself.

View solution

Q. ____ wobble pairs may be produced in these double-stranded regions.

View solution

Q. In predicting RNA secondary structure, some simplifying assumptions are usually made, like the _____ structure is similar to the _____

View solution

Q. The Second assumption in predicting RNA secondary structure is that the energy associated with any position in the structure is _____ influenced by local sequence and structure.

View solution

Q. The third assumption in predicting RNA secondary structure is that the structure is assumed to be formed by _____ of the chain back on itself in a manner that ________

View solution

Q. Martinez (1984) made a list of possible double-stranded regions, and these regions were then given weights in proportion to their equilibrium constants, calculated by ______

View solution

Q. In 1971, first estimation of the energy associated with regions of secondary structure by extrapolation from studies with small molecules was done and then an attempt was made to predict which configurations of larger molecules were the most energetically stable.

View solution

Q. Nussinov and Jacobson (1980) were the first to design a precise and efficient algorithm for predicting secondary structure.

View solution

Q. Which of the following is incorrect about the prediction of RNA secondary structure?

View solution

Q. Through a single scoring matrix, evaluation of all the different possible configurations is done.

View solution

Q. The object is to find a diagonal row of matches that goes from upper left to lower right.

View solution

Q. The increase depends on the type and length of loop that is introduced by the non-complementary base pair, whether internal loop, bulge loop, or hairpin loop.

View solution

Q. The sequence is listed down the first column of base comparisons’ table and free energy calculations’ table in the 5’→3’ orientation.

View solution