Question

A method of sequence alignment based on a Model (Bishop and Thompson 1986) was introduced that predicts the manner in which DNA sequences change during evolution. Which of the following is wrong about it?

a.

This method is different from the Smith-Waterman local alignment algorithm

b.

This method is quite similar to the Smith-Waterman local alignment algorithm

c.

The underlying mutational theory is like those used to produce the PAM matrices for predicting changes in DNA and protein sequences

d.

Sequences are predicted to change by a Markov process such that each mutation in the sequence is independent of previous mutations at that site or at other sites

Answer: (b).This method is quite similar to the Smith-Waterman local alignment algorithm

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Q. A method of sequence alignment based on a Model (Bishop and Thompson 1986) was introduced that predicts the manner in which DNA sequences change during evolution. Which of the...

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