Q. GenomeScan is a web-based server that combines GENSCAN prediction results with BLASTX similarity searches.

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Q. Which of the following is untrue about EST2Genome?

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Q. Which of the following is untrue about SGP-1?

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Q. TwinScan is also a similarity-based gene-finding Server and it is similar to GenomeScan in that it uses GenScan to predict all possible exons from the genomic sequence.

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Q. Because different prediction programs have different levels of sensitivity and specificity, it makes sense to combine results of multiple programs based on consensus. This idea has prompted development of consensus-based algorithms.

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Q. In bacteria, transcription is initiated by DNA polymerase.

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Q. The upstream sequence where the σ protein binds constitutes the promoter sequence.

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Q. The promoter sequence may determine the expression of one gene or a number of linked genes downstream.

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Q. In addition to the RNA polymerase, there are also a number of DNA-binding proteins that facilitate the process of transcription.

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Q. The specific DNA sequences to which the transcription factors bind are referred to as _____

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Q. In eukaryotes, gene expression is not regulated by a protein complex formed between transcription factors and RNA polymerase.

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Q. Which of the following is untrue?

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Q. In eukaryotes, genes often form an operon with a shared promoter.

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Q. Eukaryotic RNA polymerase II does not directly bind to the promoter, but relies on a dozen or more transcription factors to recognize and bind to the promoter in a specific order before its own binding around the promoter.

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Q. The TATA box is often used as an indicator of the presence of a promoter.

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Q. Ab initio type of algorithm predicts prokaryotic and eukaryotic promoters and regulatory elements based on characteristic sequences patterns for promoters and regulatory elements.

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Q. The advantage of the ab initio method is that the sequence can be applied as such without having to obtain experimental information.

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Q. Which of the following is incorrect regarding the ab initio approaches?

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Q. To improve the specificity of prediction, some algorithms selectively ______ coding regions and focus on the upstream regions________ which are most likely to contain promoters. In that sense, promoter prediction and gene prediction are coupled.

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Q. Operon prediction is less important in prokaryotic promoter prediction.

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