Q. An approach to classification of genes that encode enzymes is to examine relationships among multiple enzymes that perform the same biochemical function in the same organism.

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Q. Other functional classification schemes for genes include a broader category for genes involved in the same biological process, e.g., a three-group scheme for energy-related, information-related, and communication-related genes has also been used.

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Q. Two species that have recently diverged from a common ancestor might be expected to have a ________ set of genes and ________ chromosomes with these genes positioned along the chromosomes in the same order.

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Q. Which of the given statement is incorrect about the observations made with regard to gene order?

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Q. Which of the given statement is incorrect about the Chromosomal Rearrangements?

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Q. Which of the given statement is incorrect?

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Q. Which of the given statements is incorrect about global gene regulation?

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Q. Which of the given statements is incorrect about Microarray (or microchip) analysis?

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Q. Once a set of genes that are co-regulated has been found, the promoter regions of these genes may be analyzed for conserved patterns that represent sites of interaction with specific transcription factors.

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Q. Which of the given statements is incorrect about Microarray Analysis?

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Q. In cluster analysis of microarray data– If Xi is the log odds value for gene X at time i, then for two genes X and Y and N observations, a similarity score is calculated. S(X,Y) is also known as the Pearson correlation coefficent. Xoffset and Yoffset can be the mean of the observations on X or Y, respectively, in which case is the standard deviation, or else Xoffset and Yoffset can be set to zero when a reference state is used. Which of the following best represents it?

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Q. In cluster analysis of microarray data– A node is created between the _________ scoring pair, and the gene expressed profiles of these two genes are averaged and the joined elements are weighted by the _________ of elements they contain.

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Q. In cluster analysis of microarray data– For n genes, the process is repeated ________ times until a single element remains.

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Q. The hierarchical clustering method generates a similarity score [S(X,Y)] for all gene combinations, places the scores in a matrix, joins those genes that have the highest score, and then continues to join progressively less similar pairs.

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Q. In Self-organizing maps a choice is made of a number of clusters by which to organize the data.

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Q. SVMs (Support vector machines) are a binary classification method to discriminate one set of data points from another.

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Q. In SVMs (Support vector machines) Data points are log-transformed and normalized as in method A, where for N observations of a gene i, the log transform Xi of the expression level Ei and reference level Ri is?

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Q. When two proteins share a considerable degree of sequence identity throughout the sequence alignment, they are least likely to share the same function.

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Q. Other types of evidence for a relationship between two genes are also given that are not dependent in sequence similarity. Which of the following is a wrong statement?

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Q. In Genome-wide prediction of protein functions by a combinatorial method– Each point represents a protein, and branches between proteins indicate a relationship by one of several criteria indicated in the legend.

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