Q. Interwound writhe and spiral writhe are topologically different.

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Q. Twist and writhe are interconvertible.

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Q. What is the relation between linking number (Lk), writing number (Wr) and twist number (Tw)?

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Q. How can we remove supercoils from cccDNA?

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Q. How is the extent of supercoiling measured?

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Q. If Lk < Lkᵒ then DNA is ____________

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Q. What is ΔLk and Lkᵒ dependent upon?

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Q. Strand separation is easily accomplished in positively supercoiled DNA.

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Q. Which of the following organism has been found to have a positively supercoiled DNA?

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Q. Which of the following is not true about positive supercoils?

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Q. Packaging of DNA around nucleosome is known as ____________

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Q. The nucleosome is seen to have negative supercoils.

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Q. Which of the following is known to relax supercoiled DNA?

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Q. With respect to topoisomerases which of the following is true?

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Q. Topoisomerases I and II differ only on the number of steps required to change the linking number.

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Q. Which special enzyme introduces negative supercoils in DNA?

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Q. Which of the following is not a property of topoisomerase?

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Q. Topoisomerases introduces catenation to promote cell division.

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Q. Type I topoisomerase can never decatenate catenated circular DNA?

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Q. The promotion of DNA breaking and rejoining by topoisomerase requires______________

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