Q. In an experiment to check mutagenicity of a substance, we feed the mutagen to a rat and then use the rat _______ extract within the media. This ensures_____________

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Q. Which of this mutagen can lead to both AT->GC and GC->AT transition?

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Q. Which of the following modes of repair is restricted to S phase of the cell cycle?

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Q. DNA microsatellites are prone to which type of mutation?

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Q. In an experiment you make two setups, in 1st you knock down the DAM and in 2nd you over express DAM. What will be the observation for both the setups?

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Q. Which of the following factors in MMR can recognize the mismatch?

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Q. If the nick is at 5’ end of the mismatch which of the following will be recruited?

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Q. Which MMR protein homologue has not yet been discovered in eukaryotes?

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Q. Which of the following disease in humans is due to the error in MMR?

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Q. Which of the following mismatches will be ignored by MMR?

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Q. Mut H acts as ______________

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Q. 6, 4 PP are brought about by which type of mutagen?

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Q. Which of the following is not a function of APE1?

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Q. Which of the DNA polymerase in prokaryotes is responsible for re-synthesizing the stretch in MMR?

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Q. GATC sequence on either side of the mismatch can help in MMR.

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Q. Which DNA polymerase plays a role in repair synthesis in BER in prokaryotes?

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Q. BER detects wrong bases by __________________

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Q. AP endonuclease can cleave the DNA at__________ while AP lyase will cleave the DNA at__________

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Q. Which of the following can’t be repaired by BER?

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Q. Which of the bond in the nucleotide is broken 1st in BER?

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