Q. If the purpose is to calculate the probability of one event AND a second event, the odds scores for the events are _________

View solution

Q. In a type of probability, analysis is to calculate the odds score for one event OR a second event, or of a series of events. In this case, the odds scores are _______

View solution

Q. In Bayesian methods, difficulty with making estimations is that the estimate depends on the following Assumption.
(Assumption – The mutation rate in sequences has been constant with time and that the rate of mutation of all nucleotides is the same.)

View solution

Q. Another difficulty in Bayesian methods is deciding on the length of sequence that was duplicated.

View solution

Q. A length and distance that gives the highest overall probability may then be determined. Such alignments are initially found using ________

View solution

Q. Which of the following feature of Bayesian methods is the disadvantage of it?

View solution

Q. Zhu (1998) have devised a computer program called the Bayes block aligner which in effect slides ____ sequences along each other to find the ______ ungapped regions or blocks.

View solution

Q. Unlike the commonly used methods for aligning a pair of sequences, the Bayesian method _______ using a particular scoring matrix or designated gap penalties.

View solution

Q. Which of the following is incorrect regarding pair wise sequence alignment?

View solution

Q. Which of the following is incorrect about evolution?

View solution

Q. The presence of evolutionary traces is because some of the residues that perform key functional and structural roles tend to be preserved by natural selection; other residues that may be less crucial for structure and function tend to mutate more frequently.

View solution

Q. The degree of sequence variation in the alignment reveals evolutionary relatedness of different sequences, whereas the conservation between sequences reflects the changes that have occurred during evolution in the form of substitutions, insertions, and deletions.

View solution

Q. If the two sequences share significant similarity, it is extremely ______ that the extensive similarity between the two sequences has been acquired randomly, meaning that the two sequences must have derived from a common evolutionary origin.

View solution

Q. Sometimes, it is also possible that two sequences have derived from a common ancestor, but may have diverged to such an extent that the common ancestral relationships are not recognizable at the sequence level.

View solution

Q. Which of the following is incorrect regarding sequence homology?

View solution

Q. Sequence similarity can be quantified using ________ homology is a ______ statement.

View solution

Q. Shorter sequences require higher cutoffs for inferring homologous relationships than longer sequences.

View solution

Q. Sequence similarity and sequence identity are synonymous for nucleotide sequences and protein sequences as well.

View solution

Q. The overall goal of pair wise sequence alignment is to find the best pairing of two sequences, such that there is maximum correspondence among residues.

View solution

Q. In local alignment, the two sequences to be aligned cannot be of unequal lengths.

View solution