Q. In local alignment, the two sequences to be aligned cannot be of unequal lengths.

View solution

Q. Alignment algorithms, both global and local, are fundamentally similar and only differ in the optimization strategy used in aligning similar residues.

View solution

Q. In a dot matrix, two sequences to be compared are written in the _____________ of the matrix.

View solution

Q. When the two sequences have substantial regions of similarity, many dots line up to form contiguous _______ lines.

View solution

Q. A problem exists when comparing _____ sequences using the dot matrix method, namely, the _______

View solution

Q. If the selected window size is too long, sensitivity of the alignment is lost.

View solution

Q. A sequence can be aligned with itself to identify internal repeat elements.

View solution

Q. Self complementarity of DNA sequences cannot be identified using a dot plot.

View solution

Q. Which of the following is untrue about dot plot method and its applications?

View solution

Q. The truly statistically significant sequence alignment will be able to provide evidence of homology between the sequences involved.

View solution

Q. By calculating alignment scores of a large number of ______ sequence pairs, a distribution model of the ______ sequence scores can be derived.

View solution

Q. Many studies have demonstrated that the distribution of similarity scores assumes a peculiar shape that resembles a highly skewed normal distribution with a long tail on one side. The distribution matches the _______

View solution

Q. Which of the following is a part of the statistical test of sequences?

View solution

Q. In the statistical test, randomization process in which one of the two given sequences is randomly shuffled.

View solution

Q. What is used to generate parameters for the extreme distribution?

View solution

Q. If the score is located in the extreme margin of the distribution, that means that the alignment between the two sequences is ______ due to random chance and is thus considered ______

View solution

Q. It is not known whether the Gumble distribution applies equally well to gapped alignments.

View solution

Q. Which of the following is untrue about the PRSS program?

View solution

Q. The major disadvantage of the PRSS program is that it doesn’t allow partial shuffling.

View solution