Q. Which of the following is untrue about dot plot method and its applications?

View solution

Q. Self complementarity of DNA sequences cannot be identified using a dot plot.

View solution

Q. A sequence can be aligned with itself to identify internal repeat elements.

View solution

Q. If the selected window size is too long, sensitivity of the alignment is lost.

View solution

Q. A problem exists when comparing _____ sequences using the dot matrix method, namely, the _______

View solution

Q. When the two sequences have substantial regions of similarity, many dots line up to form contiguous _______ lines.

View solution

Q. In a dot matrix, two sequences to be compared are written in the _____________ of the matrix.

View solution

Q. Alignment algorithms, both global and local, are fundamentally similar and only differ in the optimization strategy used in aligning similar residues.

View solution

Q. In local alignment, the two sequences to be aligned cannot be of unequal lengths.

View solution

Q. The overall goal of pair wise sequence alignment is to find the best pairing of two sequences, such that there is maximum correspondence among residues.

View solution

Q. Sequence similarity and sequence identity are synonymous for nucleotide sequences and protein sequences as well.

View solution

Q. Shorter sequences require higher cutoffs for inferring homologous relationships than longer sequences.

View solution

Q. Sequence similarity can be quantified using ________ homology is a ______ statement.

View solution

Q. Which of the following is incorrect regarding sequence homology?

View solution

Q. Sometimes, it is also possible that two sequences have derived from a common ancestor, but may have diverged to such an extent that the common ancestral relationships are not recognizable at the sequence level.

View solution

Q. If the two sequences share significant similarity, it is extremely ______ that the extensive similarity between the two sequences has been acquired randomly, meaning that the two sequences must have derived from a common evolutionary origin.

View solution

Q. The degree of sequence variation in the alignment reveals evolutionary relatedness of different sequences, whereas the conservation between sequences reflects the changes that have occurred during evolution in the form of substitutions, insertions, and deletions.

View solution

Q. The presence of evolutionary traces is because some of the residues that perform key functional and structural roles tend to be preserved by natural selection; other residues that may be less crucial for structure and function tend to mutate more frequently.

View solution

Q. Which of the following is incorrect about evolution?

View solution

Q. Which of the following is incorrect regarding pair wise sequence alignment?

View solution