Q. What is used to generate parameters for the extreme distribution?

View solution

Q. In the statistical test, randomization process in which one of the two given sequences is randomly shuffled.

View solution

Q. Which of the following is a part of the statistical test of sequences?

View solution

Q. Many studies have demonstrated that the distribution of similarity scores assumes a peculiar shape that resembles a highly skewed normal distribution with a long tail on one side. The distribution matches the _______

View solution

Q. By calculating alignment scores of a large number of ______ sequence pairs, a distribution model of the ______ sequence scores can be derived.

View solution

Q. The truly statistically significant sequence alignment will be able to provide evidence of homology between the sequences involved.

View solution

Q. Which of the following is untrue about dot plot method and its applications?

View solution

Q. Self complementarity of DNA sequences cannot be identified using a dot plot.

View solution

Q. A sequence can be aligned with itself to identify internal repeat elements.

View solution

Q. If the selected window size is too long, sensitivity of the alignment is lost.

View solution

Q. A problem exists when comparing _____ sequences using the dot matrix method, namely, the _______

View solution

Q. When the two sequences have substantial regions of similarity, many dots line up to form contiguous _______ lines.

View solution

Q. In a dot matrix, two sequences to be compared are written in the _____________ of the matrix.

View solution

Q. Alignment algorithms, both global and local, are fundamentally similar and only differ in the optimization strategy used in aligning similar residues.

View solution

Q. In local alignment, the two sequences to be aligned cannot be of unequal lengths.

View solution

Q. The overall goal of pair wise sequence alignment is to find the best pairing of two sequences, such that there is maximum correspondence among residues.

View solution

Q. Sequence similarity and sequence identity are synonymous for nucleotide sequences and protein sequences as well.

View solution

Q. Shorter sequences require higher cutoffs for inferring homologous relationships than longer sequences.

View solution

Q. Sequence similarity can be quantified using ________ homology is a ______ statement.

View solution

Q. Which of the following is incorrect regarding sequence homology?

View solution