Q. The Genetic Algorithm method has been recently adapted for MSA(Multiple Sequence Alignment) by Corpet (1998).

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Q. An approach for obtaining a higher-scoring MSA (Multiple Sequence Alignment) by rearranging an existing alignment uses a probability approach called simulated annealing.

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Q. The first step in Genetic Algorithm is arranging the sequences to be aligned in rows.

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Q. The second step in the Genetic Algorithm comprises of scoring of the 100 initial MSAs by the sum of pairs method.

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Q. In Genetic Algorithm, in the mutation process _______

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Q. The HMM is a statistical model that considers few combinations of matches and gaps to generate an alignment of a set of sequences.

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Q. Which of the following is not true about iterative methods?

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Q. Which of the following is not among the methods for finding localized sequence similarity?

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Q. Profiles are found by performing the _____ MSA of a group of sequences and then removing the _______ regions in the alignment into a smaller MSA.

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Q. The program Profilemake can be used to produce a profile from an MSA.

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Q. Which of the following is untrue regarding the block analysis method?

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Q. Block analysis methods use substitution matrices such as the PAM and BLOSUM matrices to score matches.

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Q. In the method of extraction of blocks from a global or local MSA, a global MSA of related protein sequences usually includes regions that have been aligned without gaps in any of the sequences.

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Q. Which of the following is not true regarding the BLOCKS?

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Q. The pattern searching method type of analysis was performed on groups of related proteins, and the amino acid patterns that were located may be found in the Prosite catalog.

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Q. Although MOTIF program is used successfully for making the BLOCKS database, it is limited in the pattern sizes that can be found.

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Q. Which of the following is not true regarding the BLOCKS?

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Q. The Expectation Maximization algorithm has been used to identify conserved domains in unaligned proteins only.

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Q. Which of the following is untrue regarding Expectation Maximization algorithm?

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Q. Out of the two repeated steps in EM algorithm, the step 2 is ________

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