Q. There are a large number of protein folds available, compared to millions of protein sequences.

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Q. Threading or structural fold recognition predicts the structural fold of an unknown protein sequence by fitting the sequence into a structural database and selecting the best-fitting fold.

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Q. The algorithms used here can be classified into two categories, pairwise energy based and profile based.

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Q. In the pairwise energy based method, a protein sequence is searched for in a structural fold database to find the best matching structural fold using ______ criteria.

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Q. The next step in the pairwise energy based method is to build a crude model for the target sequence by replacing aligned residues in the template structure with the corresponding residues in the query.

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Q. Which of the following is untrue about profile method?

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Q. Because threading and fold recognition detect structural homologs ________ relying on sequence similarities, they have been shown to be _______ than PSI-BLAST in finding distant evolutionary relationships

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Q. Which of the following is untrue about threading and fold recognition?

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Q. Which of the following is untrue about 3D-PSSM?

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Q. Which of the following is true about Gen Threader?

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