Q. One centiMorgan is defined as _________ percentage of the total recombination events.

View solution

Q. Physical maps are maps of locations of identifiable landmarks on a genomic DNA _______ inheritance patterns.

View solution

Q. Physical maps are constructed by using a chromosome walking technique.

View solution

Q. Which of the following is untrue about cytologic maps?

View solution

Q. Cytologic maps can be considered to be of _____ resolution and hence somewhat ______ physical maps.

View solution

Q. In medical applications, the ultimate goal of gene mapping is to disease genes.

View solution

Q. One of the fundamental events that occur in meiosis is crossing over in which homologous chromosomes exchange segments causing a reshuffling of genes.

View solution

Q. The _____ resolution genome map is the genomic DNA sequence that can be considered as a type of ______ map describing a genome at the single base-pair level.

View solution

Q. Which of the following is untrue about DNA sequencing?

View solution

Q. In DNA sequencing, the fluorescent traces of the DNA sequences are read by a computer program that assigns bases for each peak in a chromatogram.

View solution

Q. The shotgun approach _______ sequences clones from _____ of cloned DNA.

View solution

Q. The shotgun approach does not require knowledge of physical mapping of the clone fragments, but rather a robust computer assembly program to join the pieces of random fragments into a single, whole-genome sequence.

View solution

Q. Despite the multiple coverage, sometimes certain genomic regions remain unsequenced, mainly owing to cloning difficulties.

View solution

Q. The hierarchical genome sequencing approach is ______

View solution

Q. In hierarchical genome sequencing approach, based on the results of _______ mapping _______of the BAC clones on a chromosome can be determined.

View solution

Q. The hierarchical approach is ____ and _____ than the shotgun approach because it involves an initial clone-based physical mapping step.

View solution

Q. The whole genome shotgun approach can produce a draft sequence very rapidly because it is based on the direct sequencing approach.

View solution

Q. The major challenges in genome assembly are sequence errors, contamination by bacterial vectors, and repetitive sequence regions.

View solution

Q. When a sequence is generated from ____ ends of a single clone, the distance between the two opposing fragments of a clone is fixed to ________ meaning that they are always separated by a distance defined by a _____ length (normally 1,000 to 9,000 bases).

View solution

Q. Which of the following is untrue about base calling and assembly programs?

View solution