Q. In the ab initio–based approaches—they rely on two major features associated with genes: one of them being gene content, which is statistical description of coding regions.

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Q. The homology-based method makes predictions based on significant matches of the query sequence with sequences of known genes.

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Q. FGENESB is a web-based program that is also based on fifth-order HMMs for detecting coding regions.

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Q. Which of the following is untrue about GeneMark?

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Q. Which of the following is untrue about Glimmer?

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Q. RBS finder is a UNIX program that uses the prediction output from Glimmer and searches for the Shine–Delgarno sequences in the vicinity of predicted start sites.

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Q. Which of the following is a wrong statement?

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Q. In bacteria, the majority of genes have a start codon ATG (orAUG in mRNA; because prediction is done at the DNA level, T is used in place of U), which codes for methionine.

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Q. The presence of these codons at The beginning of the frame _____ give a clear indication of the translation initiation site.

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Q. Shine-Delgarno sequence, which is a stretch of purine-rich sequence complementary to 16S rRNA in the ribosome.

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Q. There are ____ possible stop codons, identification of which is straightforward.

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Q. Which of the following is a wrong statement regarding the conventional determination of open reading frames?

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Q. The putative ORF can be translated into a protein sequence, which is then used to search against a protein database.

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Q. Which of the following is a wrong statement regarding TESTCODE method?

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Q. The conventional determination of open reading methods identify only typical genes and tend to miss atypical genes in which the rule of codon bias is not strictly followed.

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Q. Which of the following is a wrong statement regarding Gene Prediction Using Markov Models and Hidden Markov Models?

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Q. The use of Markov models in gene finding exploits the fact that oligonucleotide distributions in the coding regions are different from those for the noncoding regions.

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Q. Because a protein-encoding gene is composed of nucleotides in triplets as codons, more effective Markov models are built in sets of three nucleotides, describing nonrandom distributions of trimers or hexamers, and so on.

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Q. Which of the following is untrue?

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Q. Which of the following is untrue about translation and transcription?

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