Q. An understanding of the importance of different factors in a particular interaction is important if confidence in the results is required. Which of the following are not those factors?

View solution

Q. Information about shape, hydrophobicity, electrostatics, evolutionary relationships and conformational flexibility is not always available and the search for a universally applicable scoring function as well as an adequate treatment of conformational flexibility is ongoing.

View solution

Q. In practical circumstances there exists an experimental structure of the complex.

View solution

Q. Visualization methods are very important in viewing molecular properties on molecules. Of particular note is the rendering of molecular surfaces according to their various properties (that can be expressed numerically).

View solution

Q. The popular program RasMol can be made to view molecular properties by assigning those properties to the temperature factor column of the sdf file in question only.

View solution

Q. The GRASP and VRLM have been incorporated into the GRASS server.

View solution

Q. The physical contacts between domains are crucial for the functioning of the cellular machinery.

View solution

Q. There exist three types of interactions between domains. Which of the following is not one of them?

View solution

Q. Stable complexes consist of proteins that are _____ associated with each other, like many ____ proteins for instance.

View solution

Q. Sets of proteins that are part of stable complexes and sets of proteins involved in transient interactions ____ in terms of the similarity in gene expression among the set of proteins.

View solution

Q. Correlation of gene expression for pairs of transiently interacting proteins is ______ compared to randomly chosen pairs of proteins.

View solution

Q. Membership in a stable complex also differs from transient interaction in terms of evolutionary constraints upon sequence divergence.

View solution

Q. For proteins in stable complexes the average sequence identity is 46%, while for proteins in transient interactions it is 41%.

View solution

Q. Which of the following is incorrect about Yeast-two-hybrid screens?

View solution

Q. Which of the following is incorrect about Purification of protein complexes followed by mass spectrometry?

View solution

Q. Which of the following is untrue?

View solution

Q. In protein domain family interaction map, the physical contacts of the domains in different families are represented by the lines between the nodes.

View solution

Q. In the Interaction map of domain families, the interactions of one family represent the sum of all the interactions of domains in that family.

View solution

Q. Most domain families only interact with one or two other families, while a few families are extremely versatile in their interactions and are connected to many families.

View solution

Q. Almost ______ engage in interactions with domains from their own family when one includes oligomeric proteins.

View solution