Q. The phylogenetic profile method relies on detection of orthologs (or homologs, in a variation of the method) in a set of genomes.

View solution

Q. Due to the requirement for co-regulation as well as colocalization, the method is mostly limited to certain classes of protein-protein interactions.

View solution

Q. Domains that are part of a multidomain protein are ______

View solution

Q. An approach for predicting ______ to look for cases across a set of genomes where _____ are part of the same gene in one genome resulted in gene fusion method.

View solution

Q. Conservation of gene order due to operon structure is _______ so interactions of proteins specific to eukaryotes cannot be detected by method of Conservation of gene order.

View solution

Q. In a quantitative assessment of this method (Conservation of gene order) using the genome of the parasitic organism Mycoplasma genitalium as a benchmark.

View solution

Q. Members of a stable complex are often co-regulated and thus will be detected by the method of Conservation of gene order.

View solution

Q. When comparing pairs of genes or sets of genes in different genomes for this purpose, it is not mandatory for the genes to be orthologs.

View solution

Q. Genes that are consistently part of the same operon across different, distantly related genomes are likely to be part of the same protein complex or functional process across all species.

View solution

Q. Interactions between proteins can be predicted computationally by looking for sets of genes that occur as a _______

View solution

Q. Experimentation is most desirable over computational methods by every means.

View solution

Q. Across the different types of catalytic families, the position of the two domains with respect to one another varied, but only within a range of about ______

View solution

Q. The linkers between the catalytic domain and the Rossmann domain were conserved in each family.

View solution

Q. The investigation (Aloy and Russel) of domain combinations in multidomain proteins by Bashton and Chothia focuses on two-domain proteins belonging to the Rossmann domain family.

View solution

Q. In order to understand the geometry of domain combinations, different structures of homologous pairs of domains must be studied.

View solution

Q. Almost ______ engage in interactions with domains from their own family when one includes oligomeric proteins.

View solution

Q. Most domain families only interact with one or two other families, while a few families are extremely versatile in their interactions and are connected to many families.

View solution

Q. In the Interaction map of domain families, the interactions of one family represent the sum of all the interactions of domains in that family.

View solution

Q. In protein domain family interaction map, the physical contacts of the domains in different families are represented by the lines between the nodes.

View solution

Q. Which of the following is untrue?

View solution