Question

Some genetic diseases cannot be diagnosed by changes in restriction sites. Some of these can be detected by allele-specific oligonucleotide probes. These are

a.

copies of the gene with an altered sequence so that a restriction site is inserted

b.

mutagenized copies of a gene

c.

short sequences that will hybridize only to a specific base sequence

d.

PCR-amplified variable numbers of tandem repeats (VNTRs)

Posted under Biochemistry

Answer: (c).short sequences that will hybridize only to a specific base sequence

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Q. Some genetic diseases cannot be diagnosed by changes in restriction sites. Some of these can be detected by allele-specific oligonucleotide probes. These are
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