Q. Rigorously evaluating the performance of RNA prediction programs has traditionally been hindered by the dearth of three-dimensional structural information for RNA.

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Q. If prediction accuracy can be represented using a ______ the ______ programs score roughly 20% to 60% depending on the length of the sequences.

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Q. For _________ RNA sequences, such as tRNA, some programs may be able to produce _________% accuracy.

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Q. The pre-alignment independent programs fare __________ for predicting long sequences.

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Q. Based on recent benchmark comparisons, the comparative-type algorithms can reach an accuracy range of 20% to 80%.

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Q. In comparative approach to RNA structure prediction, algorithms that do not use pre-alignment, align multiple input sequences and infers a consensus structure.

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Q. In comparative approach to RNA structure prediction, Foldalign is a web-based only program for RNA alignment

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Q. In comparative approach to RNA structure prediction, the Foldalign program doesn’t use the covariation information.

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Q. In comparative approach to RNA structure prediction, Dynalign is a ________ program.

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Q. In comparative approach to RNA structure prediction, in Dynalign program–by comparing _________ from each sequence, a ______ structure common to both sequences is selected that serves as the basis for sequence alignment.

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Q. Which of the following is incorrect about the RNA structure prediction?

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Q. A type of RNA secondary structure prediction method takes into account conserved patterns of base-pairing that are conserved during evolution of a given class of RNA molecules.

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Q. RNA secondary structure is composed primarily of triple-stranded RNA regions formed by folding the single-stranded molecule back twice on itself.

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Q. ____ wobble pairs may be produced in these double-stranded regions.

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Q. In predicting RNA secondary structure, some simplifying assumptions are usually made, like the _____ structure is similar to the _____

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Q. The Second assumption in predicting RNA secondary structure is that the energy associated with any position in the structure is _____ influenced by local sequence and structure.

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Q. The third assumption in predicting RNA secondary structure is that the structure is assumed to be formed by _____ of the chain back on itself in a manner that ________

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Q. Martinez (1984) made a list of possible double-stranded regions, and these regions were then given weights in proportion to their equilibrium constants, calculated by ______

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Q. In 1971, first estimation of the energy associated with regions of secondary structure by extrapolation from studies with small molecules was done and then an attempt was made to predict which configurations of larger molecules were the most energetically stable.

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Q. Nussinov and Jacobson (1980) were the first to design a precise and efficient algorithm for predicting secondary structure.

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