Q. Genetic markers are ______ portions of a _______ whose inheritance patterns can be followed.

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Q. Genetic linkage maps, also called genetic maps, identify the relative positions of genetic markers on a chromosome and are based on how frequent the markers are inherited together.

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Q. One centiMorgan is defined as _________ percentage of the total recombination events.

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Q. Physical maps are maps of locations of identifiable landmarks on a genomic DNA _______ inheritance patterns.

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Q. Physical maps are constructed by using a chromosome walking technique.

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Q. Which of the following is untrue about cytologic maps?

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Q. Cytologic maps can be considered to be of _____ resolution and hence somewhat ______ physical maps.

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Q. In medical applications, the ultimate goal of gene mapping is to disease genes.

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Q. One of the fundamental events that occur in meiosis is crossing over in which homologous chromosomes exchange segments causing a reshuffling of genes.

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Q. The _____ resolution genome map is the genomic DNA sequence that can be considered as a type of ______ map describing a genome at the single base-pair level.

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Q. Which of the following is untrue about DNA sequencing?

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Q. In DNA sequencing, the fluorescent traces of the DNA sequences are read by a computer program that assigns bases for each peak in a chromatogram.

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Q. The shotgun approach _______ sequences clones from _____ of cloned DNA.

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Q. The shotgun approach does not require knowledge of physical mapping of the clone fragments, but rather a robust computer assembly program to join the pieces of random fragments into a single, whole-genome sequence.

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Q. Despite the multiple coverage, sometimes certain genomic regions remain unsequenced, mainly owing to cloning difficulties.

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Q. The hierarchical genome sequencing approach is ______

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Q. In hierarchical genome sequencing approach, based on the results of _______ mapping _______of the BAC clones on a chromosome can be determined.

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Q. The hierarchical approach is ____ and _____ than the shotgun approach because it involves an initial clone-based physical mapping step.

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Q. The whole genome shotgun approach can produce a draft sequence very rapidly because it is based on the direct sequencing approach.

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Q. The major challenges in genome assembly are sequence errors, contamination by bacterial vectors, and repetitive sequence regions.

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