E-PolyLearning

46. When protein binds two ligands in a non-cooperative manner, then the x-intercept of the Scatchard Plot is
a. 1
b. 2
c. not defined
d. none of the above
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Answer: (b).2

47. O₂ binding to hemoglobin results in
a. 100-fold higher affinity for the last O₂ bound than for the first
b. extensive protein conformational change
c. both (a) and (b)
d. 100-fold lower affinity for the last O₂ bound than for the first
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Answer: (c).both (a) and (b)

48. In hemoglobin, allosteric effects occur
a. only in humans
b. for maintaining Fe in the Fe2+ state
c. to minimize oxygen delivery to the tissues
d. to maximize oxygen delivery to the tissues
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Answer: (d).to maximize oxygen delivery to the tissues

49. A protein that binds two ligands in a non-cooperative manner will show
a. a sigmodial binding curve
b. a hyperbolic binding curve
c. a linear Scatchard Plot
d. both (b) and (c)
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Answer: (d).both (b) and (c)

50. Small molecules affect hemoglobin (Hb) by
a. decreasing Hb affinity for O₂
b. increasing [H+]
c. increasing Hb affinity for O₂
d. increasing [H+] and decreasing Hb affinity for O₂
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Answer: (d).increasing [H+] and decreasing Hb affinity for O₂