DNA and Genomic Sequencing MCQs

Welcome to our comprehensive collection of Multiple Choice Questions (MCQs) on DNA and Genomic Sequencing, a fundamental topic in the field of Bioinformatics. Whether you're preparing for competitive exams, honing your problem-solving skills, or simply looking to enhance your abilities in this field, our DNA and Genomic Sequencing MCQs are designed to help you grasp the core concepts and excel in solving problems.

In this section, you'll find a wide range of DNA and Genomic Sequencing mcq questions that explore various aspects of DNA and Genomic Sequencing problems. Each MCQ is crafted to challenge your understanding of DNA and Genomic Sequencing principles, enabling you to refine your problem-solving techniques. Whether you're a student aiming to ace Bioinformatics tests, a job seeker preparing for interviews, or someone simply interested in sharpening their skills, our DNA and Genomic Sequencing MCQs are your pathway to success in mastering this essential Bioinformatics topic.

Note: Each of the following question comes with multiple answer choices. Select the most appropriate option and test your understanding of DNA and Genomic Sequencing. You can click on an option to test your knowledge before viewing the solution for a MCQ. Happy learning!

So, are you ready to put your DNA and Genomic Sequencing knowledge to the test? Let's get started with our carefully curated MCQs!

DNA and Genomic Sequencing MCQs | Page 2 of 17

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Q11.
Two common goals in sequence analysis are to identify sequences that encode proteins, which determine all cellular metabolisms, and to discover sequences that regulate the expression of genes or other cellular processes.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q12.
cDNA libraries have been prepared that have the same sequences as the mRNA molecules produced by organisms, or else cDNA copies are sequenced directly by RT-PCR (copying of mRNA by reverse transcriptase followed by sequencing of the cDNA copy by the polymerase chain reaction).

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q13.
Using cDNA sequence with the __________ it is much simpler to locate protein-encoding sequences in these molecules.

a.

exons taken out

b.

exons removed

c.

introns added

d.

introns removed

Discuss
Answer: (d).introns removed
Q14.
An important development for computational purposes was the decision by Craig Venter to prepare databases of partial sequences of the expressed genes, called expressed sequence tags or ESTs.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q15.
The translated sequence can then be compared to a database of protein sequences with the hope of finding a strong similarity to a protein of known function, and hence to identify the function of the cloned EST.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q16.
Investigators are encouraged to submit their newly obtained sequences directly to a member of the International Nucleotide Sequence Database Collaboration, such as the NCBI, DDBJ, and EMBL.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q17.
NCBI reviews new entries and updates existing ones, as requested.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q18.
Which of the given statements is incorrect?

a.

The simplest and newest way of submitting sequences is through the Web site on a Web form page called BankIt

b.

The sequence can also be annotated with information about the sequence, such as mRNA start and coding regions

c.

The submitted form is transformed into GenBank format and returned to the submitter for review before being added to GenBank

d.

Sequin does not run on UNIX

Discuss
Answer: (d).Sequin does not run on UNIX
Q19.
Which of the given statements is untrue?

a.

There is no detailed check of sequence accuracy prior to submission to GenBank and other databases

b.

Often, a sequence is submitted at the time of publication of the sequence in a journal article, providing a certain level of checking by the editorial peer review process

c.

No sequence is submitted without being published or prior to publication

d.

In laboratories performing large sequencing projects, such as those engaged in the Human Genome Project or the genome projects of model organisms, the granting agency requires a certain level of accuracy of the order of 1 possible error per 10 kb

Discuss
Answer: (c).No sequence is submitted without being published or prior to publication
Q20.
Granting agency requires a certain level of accuracy in case of errors. Which of the given statements is untrue regarding it?

a.

In other laboratories, such as those performing a single-attempt sequencing of ESTs, the error rate may be much higher, approximately 1 in 100, including incorrectly identified bases and inserted or deleted bases

b.

Incorrect bases always translate to the right amino acid

c.

Base insertions/deletions will cause frame-shifts in the sequence

d.

Making alignment with a protein sequence becomes difficult because of frameshifts

Discuss
Answer: (b).Incorrect bases always translate to the right amino acid
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