Protein Biomolecular Interactions MCQs

Welcome to our comprehensive collection of Multiple Choice Questions (MCQs) on Protein Biomolecular Interactions, a fundamental topic in the field of Bioinformatics. Whether you're preparing for competitive exams, honing your problem-solving skills, or simply looking to enhance your abilities in this field, our Protein Biomolecular Interactions MCQs are designed to help you grasp the core concepts and excel in solving problems.

In this section, you'll find a wide range of Protein Biomolecular Interactions mcq questions that explore various aspects of Protein Biomolecular Interactions problems. Each MCQ is crafted to challenge your understanding of Protein Biomolecular Interactions principles, enabling you to refine your problem-solving techniques. Whether you're a student aiming to ace Bioinformatics tests, a job seeker preparing for interviews, or someone simply interested in sharpening their skills, our Protein Biomolecular Interactions MCQs are your pathway to success in mastering this essential Bioinformatics topic.

Note: Each of the following question comes with multiple answer choices. Select the most appropriate option and test your understanding of Protein Biomolecular Interactions. You can click on an option to test your knowledge before viewing the solution for a MCQ. Happy learning!

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Protein Biomolecular Interactions MCQs | Page 1 of 7

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Q1.
Membership in a stable complex also differs from transient interaction in terms of evolutionary constraints upon sequence divergence.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q2.
For proteins in stable complexes the average sequence identity is 46%, while for proteins in transient interactions it is 41%.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q3.
Which of the following is incorrect about Yeast-two-hybrid screens?

a.

The yeast-two-hybrid system uses the transcription of a reporter gene driven by the Gal4 transcription factor to monitor whether or not two proteins are interacting

b.

The DNA-binding domain chimeric protein will not bind upstream of the reporter gene

c.

If the activation domain chimeric protein interacts with the DNA-binding domain chimeric protein, the reporter gene will be transcribed

d.

Disadvantages of the method are that only pairwise interactions are tested, and not interactions that can only take place when multiple proteins come together, as well as a high false positive rate

Discuss
Answer: (b).The DNA-binding domain chimeric protein will not bind upstream of the reporter gene
Q4.
Which of the following is incorrect about Purification of protein complexes followed by mass spectrometry?

a.

Isolating protein complexes from cells allows identification of interactions between ensembles of proteins instead of just pairs

b.

Systematic purification of complexes on a large scale is done by tagging hundreds of genes with an epitope

c.

UnLike in the yeast-two-hybrid assay, this does not involve chimeric genes

d.

Affinity purification based on the epitope will then extract all the proteins attached to the bait protein from cell lysates

Discuss
Answer: (c).UnLike in the yeast-two-hybrid assay, this does not involve chimeric genes
Q5.
Which of the following is untrue?

a.

Many entries in the Protein DataBank (PDB) are three-dimensional structures of multiple domains

b.

The structures in PDB provide experimental information about interactions between domains at atomic detail

c.

There are comparatively few three-dimensional structures compared to the amount of data available from the lower resolution large-scale experiments

d.

Many entries in the Protein DataBank (PDB) are two-dimensional structures of multiple domains

Discuss
Answer: (d).Many entries in the Protein DataBank (PDB) are two-dimensional structures of multiple domains
Q6.
In protein domain family interaction map, the physical contacts of the domains in different families are represented by the lines between the nodes.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q7.
In the Interaction map of domain families, the interactions of one family represent the sum of all the interactions of domains in that family.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q8.
Most domain families only interact with one or two other families, while a few families are extremely versatile in their interactions and are connected to many families.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q9.
Almost ______ engage in interactions with domains from their own family when one includes oligomeric proteins.

a.

one fifith of all known families

b.

one fourth of all known families

c.

all of all known families

d.

half of all known families

Discuss
Answer: (d).half of all known families
Q10.
In order to understand the geometry of domain combinations, different structures of homologous pairs of domains must be studied.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
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