Protein Biomolecular Interactions MCQs

Welcome to our comprehensive collection of Multiple Choice Questions (MCQs) on Protein Biomolecular Interactions, a fundamental topic in the field of Bioinformatics. Whether you're preparing for competitive exams, honing your problem-solving skills, or simply looking to enhance your abilities in this field, our Protein Biomolecular Interactions MCQs are designed to help you grasp the core concepts and excel in solving problems.

In this section, you'll find a wide range of Protein Biomolecular Interactions mcq questions that explore various aspects of Protein Biomolecular Interactions problems. Each MCQ is crafted to challenge your understanding of Protein Biomolecular Interactions principles, enabling you to refine your problem-solving techniques. Whether you're a student aiming to ace Bioinformatics tests, a job seeker preparing for interviews, or someone simply interested in sharpening their skills, our Protein Biomolecular Interactions MCQs are your pathway to success in mastering this essential Bioinformatics topic.

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Protein Biomolecular Interactions MCQs | Page 4 of 7

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Q31.
The physical contacts between domains are crucial for the functioning of the cellular machinery.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q32.
There exist three types of interactions between domains. Which of the following is not one of them?

a.

Stable complex

b.

Transient interaction

c.

Multi-domain protein

d.

Unstable interaction

Discuss
Answer: (d).Unstable interaction
Q33.
Stable complexes consist of proteins that are _____ associated with each other, like many ____ proteins for instance.

a.

temporarily, oligomeric

b.

temporarily, monomeric

c.

permanently, oligomeric

d.

permanently, monomeric

Discuss
Answer: (c).permanently, oligomeric
Q34.
Sets of proteins that are part of stable complexes and sets of proteins involved in transient interactions ____ in terms of the similarity in gene expression among the set of proteins.

a.

are similar

b.

differ

c.

are same

d.

show similar function

Discuss
Answer: (b).differ
Q35.
Correlation of gene expression for pairs of transiently interacting proteins is ______ compared to randomly chosen pairs of proteins.

a.

not significant

b.

only marginally significant

c.

totally significant

d.

significant to much extent

Discuss
Answer: (b).only marginally significant
Q36.
Membership in a stable complex also differs from transient interaction in terms of evolutionary constraints upon sequence divergence.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q37.
For proteins in stable complexes the average sequence identity is 46%, while for proteins in transient interactions it is 41%.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q38.
Which of the following is incorrect about Yeast-two-hybrid screens?

a.

The yeast-two-hybrid system uses the transcription of a reporter gene driven by the Gal4 transcription factor to monitor whether or not two proteins are interacting

b.

The DNA-binding domain chimeric protein will not bind upstream of the reporter gene

c.

If the activation domain chimeric protein interacts with the DNA-binding domain chimeric protein, the reporter gene will be transcribed

d.

Disadvantages of the method are that only pairwise interactions are tested, and not interactions that can only take place when multiple proteins come together, as well as a high false positive rate

Discuss
Answer: (b).The DNA-binding domain chimeric protein will not bind upstream of the reporter gene
Q39.
Which of the following is incorrect about Purification of protein complexes followed by mass spectrometry?

a.

Isolating protein complexes from cells allows identification of interactions between ensembles of proteins instead of just pairs

b.

Systematic purification of complexes on a large scale is done by tagging hundreds of genes with an epitope

c.

UnLike in the yeast-two-hybrid assay, this does not involve chimeric genes

d.

Affinity purification based on the epitope will then extract all the proteins attached to the bait protein from cell lysates

Discuss
Answer: (c).UnLike in the yeast-two-hybrid assay, this does not involve chimeric genes
Q40.
Which of the following is untrue?

a.

Many entries in the Protein DataBank (PDB) are three-dimensional structures of multiple domains

b.

The structures in PDB provide experimental information about interactions between domains at atomic detail

c.

There are comparatively few three-dimensional structures compared to the amount of data available from the lower resolution large-scale experiments

d.

Many entries in the Protein DataBank (PDB) are two-dimensional structures of multiple domains

Discuss
Answer: (d).Many entries in the Protein DataBank (PDB) are two-dimensional structures of multiple domains
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