Protein Biomolecular Interactions MCQs

Welcome to our comprehensive collection of Multiple Choice Questions (MCQs) on Protein Biomolecular Interactions, a fundamental topic in the field of Bioinformatics. Whether you're preparing for competitive exams, honing your problem-solving skills, or simply looking to enhance your abilities in this field, our Protein Biomolecular Interactions MCQs are designed to help you grasp the core concepts and excel in solving problems.

In this section, you'll find a wide range of Protein Biomolecular Interactions mcq questions that explore various aspects of Protein Biomolecular Interactions problems. Each MCQ is crafted to challenge your understanding of Protein Biomolecular Interactions principles, enabling you to refine your problem-solving techniques. Whether you're a student aiming to ace Bioinformatics tests, a job seeker preparing for interviews, or someone simply interested in sharpening their skills, our Protein Biomolecular Interactions MCQs are your pathway to success in mastering this essential Bioinformatics topic.

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Protein Biomolecular Interactions MCQs | Page 2 of 7

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Q11.
Proteins are dynamic entities that undergo _______

a.

only fluctuation of flexible loop regions about equilibrium positions when in solution

b.

only limited conformational change of amino acid side-chains when in solution

c.

both limited conformational change of amino acid side-chains and fluctuation of flexible loop regions about equilibrium positions when in solution

d.

illimitable or total conformational change of amino acid side-chains when in solution

Discuss
Answer: (c).both limited conformational change of amino acid side-chains and fluctuation of flexible loop regions about equilibrium positions when in solution
Q12.
Typical motions of proteins will be primarily treated by a rigid body model for docking.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (b).False
Q13.
In case of Protein-ligand docking, ______ ligands are often _____ in adapting their shape to fit the receptor binding pocket.

a.

small molecule, highly flexible

b.

large molecule, highly flexible

c.

large molecule, more flexible

d.

small molecule, less flexible

Discuss
Answer: (a).small molecule, highly flexible
Q14.
In Multiple conformation rigid-body method, a ligand is assumed to be able to adopt a number (N) of different _______ that are computed _____ the ligand being docked into the receptor.

a.

low-energy conformations, after

b.

low-energy conformations, prior to

c.

high-energy conformations, prior to

d.

high-energy conformations, after

Discuss
Answer: (b).low-energy conformations, prior to
Q15.
The disadvantage of Multiple conformation rigid-body method is that the active conformation may be missed as the result of a minor structural difference not considered in the ______ ligand conformations. Where, the N is the number of low-energy conformations.

a.

N +1

b.

N

c.

N²

d.

N/2

Discuss
Answer: (b).N
Q16.
In Stochastic search methods, they include methods such as Monte Carlo simulation, simulated annealing, Tabu search, genetic algorithms and evolutionary programming.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q17.
In a Monte Carlo simulation the score (or energy) is calculated at each step and compared to the previous step. The probability of accepting the step is given by _________ where ΔE is the difference in energy; kB is Boltzmann’s constant and T the temperature.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q18.
Genetic methods (genetic algorithms and evolutionary programming) store multiple solutions. These solutions form a population of members.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q19.
Stochastic methods can guarantee reaching a global optimal solution and the methods are computationally costly in comparison to the other methods.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (b).False
Q20.
Which of the following is true regarding Protein flexibility?

a.

Methods have been described for the introduction of side-chain flexibility to both protein-ligand and protein-protein docking

b.

Methods have been described for the introduction of side-chain flexibility to protein-ligand docking only

c.

The Mean Field principle is rarely used in this

d.

Methods have been described for the introduction of side-chain flexibility to protein-protein docking only

Discuss
Answer: (a).Methods have been described for the introduction of side-chain flexibility to both protein-ligand and protein-protein docking
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