Protein Biomolecular Interactions MCQs

Welcome to our comprehensive collection of Multiple Choice Questions (MCQs) on Protein Biomolecular Interactions, a fundamental topic in the field of Bioinformatics. Whether you're preparing for competitive exams, honing your problem-solving skills, or simply looking to enhance your abilities in this field, our Protein Biomolecular Interactions MCQs are designed to help you grasp the core concepts and excel in solving problems.

In this section, you'll find a wide range of Protein Biomolecular Interactions mcq questions that explore various aspects of Protein Biomolecular Interactions problems. Each MCQ is crafted to challenge your understanding of Protein Biomolecular Interactions principles, enabling you to refine your problem-solving techniques. Whether you're a student aiming to ace Bioinformatics tests, a job seeker preparing for interviews, or someone simply interested in sharpening their skills, our Protein Biomolecular Interactions MCQs are your pathway to success in mastering this essential Bioinformatics topic.

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Protein Biomolecular Interactions MCQs | Page 2 of 7

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Q11.
Proteins are dynamic entities that undergo _______

a.

only fluctuation of flexible loop regions about equilibrium positions when in solution

b.

only limited conformational change of amino acid side-chains when in solution

c.

both limited conformational change of amino acid side-chains and fluctuation of flexible loop regions about equilibrium positions when in solution

d.

illimitable or total conformational change of amino acid side-chains when in solution

Discuss
Answer: (c).both limited conformational change of amino acid side-chains and fluctuation of flexible loop regions about equilibrium positions when in solution
Q12.
Membership in a stable complex also differs from transient interaction in terms of evolutionary constraints upon sequence divergence.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q13.
For proteins in stable complexes the average sequence identity is 46%, while for proteins in transient interactions it is 41%.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q14.
Which of the following is incorrect about Yeast-two-hybrid screens?

a.

The yeast-two-hybrid system uses the transcription of a reporter gene driven by the Gal4 transcription factor to monitor whether or not two proteins are interacting

b.

The DNA-binding domain chimeric protein will not bind upstream of the reporter gene

c.

If the activation domain chimeric protein interacts with the DNA-binding domain chimeric protein, the reporter gene will be transcribed

d.

Disadvantages of the method are that only pairwise interactions are tested, and not interactions that can only take place when multiple proteins come together, as well as a high false positive rate

Discuss
Answer: (b).The DNA-binding domain chimeric protein will not bind upstream of the reporter gene
Q15.
Typical motions of proteins will be primarily treated by a rigid body model for docking.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (b).False
Q16.
In case of Protein-ligand docking, ______ ligands are often _____ in adapting their shape to fit the receptor binding pocket.

a.

small molecule, highly flexible

b.

large molecule, highly flexible

c.

large molecule, more flexible

d.

small molecule, less flexible

Discuss
Answer: (a).small molecule, highly flexible
Q17.
In Multiple conformation rigid-body method, a ligand is assumed to be able to adopt a number (N) of different _______ that are computed _____ the ligand being docked into the receptor.

a.

low-energy conformations, after

b.

low-energy conformations, prior to

c.

high-energy conformations, prior to

d.

high-energy conformations, after

Discuss
Answer: (b).low-energy conformations, prior to
Q18.
The disadvantage of Multiple conformation rigid-body method is that the active conformation may be missed as the result of a minor structural difference not considered in the ______ ligand conformations. Where, the N is the number of low-energy conformations.

a.

N +1

b.

N

c.

N²

d.

N/2

Discuss
Answer: (b).N
Q19.
In Stochastic search methods, they include methods such as Monte Carlo simulation, simulated annealing, Tabu search, genetic algorithms and evolutionary programming.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q20.
In a Monte Carlo simulation the score (or energy) is calculated at each step and compared to the previous step. The probability of accepting the step is given by _________ where Ξ”E is the difference in energy; kB is Boltzmann’s constant and T the temperature.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
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