Q. In ab initio methods for RNA structure prediction, the prediction results from RNAfold are not always guaranteed to be better than those predicted by Mfold.

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Q. The comparative approach uses basic RNA structure based predictions to infer a consensus structure.

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Q. To distinguish the conserved secondary structure among multiple related RNA sequences, a concept of “covariation” is used.

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Q. ___________ of covariation can be ___________ to the RNA structure and functions.

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Q. An aspect of the comparative method is to select a __________ structure through consensus drawing.

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Q. The comparative-based algorithms can be further divided into two categories based on the type of input data.

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Q. The type of algorithm that requires predefined alignment, requires the user to provide _______ alignment as input.

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Q. The type of algorithm that _____ predefined alignment is ______ for reasonably conserved sequences.

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Q. The predefined alignment requiring method also depends on the quality of the input alignment. If there ___ errors in the alignment, covariation signals ____ detected.

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Q. Which of the following is true about the RNAalifold?

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Q. Rigorously evaluating the performance of RNA prediction programs has traditionally been hindered by the dearth of three-dimensional structural information for RNA.

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Q. If prediction accuracy can be represented using a ______ the ______ programs score roughly 20% to 60% depending on the length of the sequences.

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Q. For _________ RNA sequences, such as tRNA, some programs may be able to produce _________% accuracy.

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Q. The pre-alignment independent programs fare __________ for predicting long sequences.

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Q. Based on recent benchmark comparisons, the comparative-type algorithms can reach an accuracy range of 20% to 80%.

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Q. In comparative approach to RNA structure prediction, algorithms that do not use pre-alignment, align multiple input sequences and infers a consensus structure.

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Q. In comparative approach to RNA structure prediction, Foldalign is a web-based only program for RNA alignment

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Q. In comparative approach to RNA structure prediction, the Foldalign program doesn’t use the covariation information.

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Q. In comparative approach to RNA structure prediction, Dynalign is a ________ program.

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Q. In comparative approach to RNA structure prediction, in Dynalign program–by comparing _________ from each sequence, a ______ structure common to both sequences is selected that serves as the basis for sequence alignment.

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