Q. In the step of Model Refinement Using Energy Function, the structural irregularities can be corrected by applying the energy minimization procedure on the entire model, which moves the atoms in such a way that the overall conformation has the lowest energy potential.

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Q. Energy minimization has to be used with caution because excessive energy minimization often moves residues away from their correct positions.

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Q. Which of the following is untrue about Ab initio prediction?

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Q. The prediction programs are thus designed using the energy minimization principle.

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Q. Searching for a fold with the absolute minimum energy may not be valid in reality.

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Q. Rosetta is a web server that predicts protein three-dimensional conformations using the ab initio method.

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Q. In Rosetta, The segments with assigned _______ structures are subsequently assembled into a ______ dimensional configuration.

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Q. There are a large number of protein folds available, compared to millions of protein sequences.

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Q. Threading or structural fold recognition predicts the structural fold of an unknown protein sequence by fitting the sequence into a structural database and selecting the best-fitting fold.

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Q. The algorithms used here can be classified into two categories, pairwise energy based and profile based.

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Q. In the pairwise energy based method, a protein sequence is searched for in a structural fold database to find the best matching structural fold using ______ criteria.

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Q. The next step in the pairwise energy based method is to build a crude model for the target sequence by replacing aligned residues in the template structure with the corresponding residues in the query.

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Q. Which of the following is untrue about profile method?

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Q. Because threading and fold recognition detect structural homologs ________ relying on sequence similarities, they have been shown to be _______ than PSI-BLAST in finding distant evolutionary relationships

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Q. Which of the following is untrue about threading and fold recognition?

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Q. Which of the following is untrue about 3D-PSSM?

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Q. Which of the following is true about Gen Threader?

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