Multiple Sequence Alignment MCQs

Welcome to our comprehensive collection of Multiple Choice Questions (MCQs) on Multiple Sequence Alignment, a fundamental topic in the field of Bioinformatics. Whether you're preparing for competitive exams, honing your problem-solving skills, or simply looking to enhance your abilities in this field, our Multiple Sequence Alignment MCQs are designed to help you grasp the core concepts and excel in solving problems.

In this section, you'll find a wide range of Multiple Sequence Alignment mcq questions that explore various aspects of Multiple Sequence Alignment problems. Each MCQ is crafted to challenge your understanding of Multiple Sequence Alignment principles, enabling you to refine your problem-solving techniques. Whether you're a student aiming to ace Bioinformatics tests, a job seeker preparing for interviews, or someone simply interested in sharpening their skills, our Multiple Sequence Alignment MCQs are your pathway to success in mastering this essential Bioinformatics topic.

Note: Each of the following question comes with multiple answer choices. Select the most appropriate option and test your understanding of Multiple Sequence Alignment. You can click on an option to test your knowledge before viewing the solution for a MCQ. Happy learning!

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Multiple Sequence Alignment MCQs | Page 2 of 8

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Q11.
Which of the following is untrue regarding the Progressive Alignment Method?

a.

Progressive alignment depends on the stepwise assembly of multiple alignments and is heuristic in nature

b.

It speeds up the alignment of multiple sequences through a multistep process

c.

It first conducts pair wise alignments for each possible pair of sequences using the Needleman–Wunsch global alignment method and records these similarity scores from the pair wise comparisons

d.

Its drawback is it slows down the alignment of multiple sequences through a single step process

Discuss
Answer: (d).Its drawback is it slows down the alignment of multiple sequences through a single step process
Q12.
Clustal is a progressive multiple alignment program available either as a stand-alone or on-line program.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q13.
Which of the following is untrue regarding the progressive alignment method?

a.

The program also applies a weighting scheme to increase the reliability of aligning divergent sequences (sequences with less than 25% identity)

b.

The progress is done by down weighting redundant and closely related groups of sequences in the alignment by a certain factor

c.

This scheme is useful in enhancing similar sequences from dominating the alignment

d.

None of the mentioned

Discuss
Answer: (c).This scheme is useful in enhancing similar sequences from dominating the alignment
Q14.
Which of the following is not a drawback of the progressive alignment method?

a.

The progressive alignment method is not suitable for comparing sequences of different lengths because it is a global alignment–based method

b.

In this method the use of affine gap penalties, long gaps are not allowed, and, in some cases, this may limit the accuracy of the method

c.

In this method the use of affine gap penalties, long gaps is allowed, and, in some cases, this may limit the accuracy of the method

d.

The final alignment result is also influenced by the order of sequence addition

Discuss
Answer: (c).In this method the use of affine gap penalties, long gaps is allowed, and, in some cases, this may limit the accuracy of the method
Q15.
Which of the following is untrue regarding T-Coffee?

a.

It stands for Tree-based Consistency Objective Function for alignment Evaluation

b.

It performs progressive sequence alignments as in Clustal.

c.

The global pair wise alignment is not performed using the Clustal program.

d.

The local pair wise alignment is generated by the Lalign program, from which the top ten scored alignments are selected

Discuss
Answer: (c).The global pair wise alignment is not performed using the Clustal program.
Q16.
Which of the following is untrue about iterative approach?

a.

The iterative approach is based on the idea that an optimal solution can be found by repeatedly modifying existing suboptimal solutions

b.

Because the order of the sequences used for alignment is different in each iteration

c.

This method is also heuristic in nature and does not have guarantees for finding the optimal alignment

d.

This method is not based on heuristic methods

Discuss
Answer: (d).This method is not based on heuristic methods
Q17.
Which of the following is untrue about PRRN?

a.

PRRN is a web-based program that uses a double nested iterative strategy for multiple alignment

b.

It performs multiple alignments through two sets of iterations: inner iteration and outer iteration

c.

In the outer iteration, an initial random alignment is generated that is used to derive a UPGMA tree

d.

In the inner iteration, the sequences are randomly divided into multiple groups

Discuss
Answer: (d).In the inner iteration, the sequences are randomly divided into multiple groups
Q18.
The major drawback of the progressive and iterative alignment strategies is that they are largely global alignment based and may therefore fail to recognize conserved domains and motifs among highly divergent sequences of varying lengths.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q19.
Which of the following is untrue about DIALIGN2?

a.

It is a web based program designed to detect local similarities

b.

It is designed to detect global similarities

c.

It does not apply gap penalties and thus is not sensitive to long gaps

d.

The method breaks each of the sequences down to smaller segments and performs all possible pair wise alignments between the segments

Discuss
Answer: (b).It is designed to detect global similarities
Q20.
Match-Box compares segments of some of the nine residues of possible Pair wise alignments.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (b).False
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