Sequence Alignment MCQs

Welcome to our comprehensive collection of Multiple Choice Questions (MCQs) on Sequence Alignment, a fundamental topic in the field of Bioinformatics. Whether you're preparing for competitive exams, honing your problem-solving skills, or simply looking to enhance your abilities in this field, our Sequence Alignment MCQs are designed to help you grasp the core concepts and excel in solving problems.

In this section, you'll find a wide range of Sequence Alignment mcq questions that explore various aspects of Sequence Alignment problems. Each MCQ is crafted to challenge your understanding of Sequence Alignment principles, enabling you to refine your problem-solving techniques. Whether you're a student aiming to ace Bioinformatics tests, a job seeker preparing for interviews, or someone simply interested in sharpening their skills, our Sequence Alignment MCQs are your pathway to success in mastering this essential Bioinformatics topic.

Note: Each of the following question comes with multiple answer choices. Select the most appropriate option and test your understanding of Sequence Alignment. You can click on an option to test your knowledge before viewing the solution for a MCQ. Happy learning!

So, are you ready to put your Sequence Alignment knowledge to the test? Let's get started with our carefully curated MCQs!

Sequence Alignment MCQs | Page 10 of 15

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Q91.
In scoring matrices, for convenience, odds scores are converted to log odds scores.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q92.
Which of the following doesn’t describe PAM matrices?

a.

This family of matrices lists the likelihood of change from one amino acid to another in homologous protein sequences during evolution

b.

There is presently no other type of scoring matrix that is based on such sound evolutionary principles as are these matrices

c.

Even though they were originally based on a relatively small data set, the PAM matrices remain a useful tool for sequence alignment

d.

It stands for Percent Altered Mutation

Discuss
Answer: (d).It stands for Percent Altered Mutation
Q93.
The assumption in this evolutionary model is that the amino acid substitutions observed over short periods of evolutionary history can be extrapolated to longer distances.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q94.
Which of the following is untrue about the modification of PAM matrices?

a.

At one time, the PAM250 scoring matrix was modified in an attempt to improve the alignment obtained

b.

All scores for matching a particular amino acid were normalized to the same mean and standard deviation, and all amino acid identities were given the same score to provide an equal contribution for each amino acid in a sequence alignment

c.

This took place in 1976

d.

These modifications were included as the default matrices for the GCG sequence alignment programs in versions 8 and earlier and are optional in later versions

Discuss
Answer: (c).This took place in 1976
Q95.
The Dayhoff model of protein evolution is not a Markov process.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (b).False
Q96.
Which of the following is true regarding the assumptions in the method of constructing the Dayhoff scoring matrix?

a.

it is assumed that each amino acid position is equally mutable

b.

it is assumed that each amino acid position is not equally mutable

c.

it is assumed that each amino acid position is not mutable at all

d.

sites do not vary in their degree of mutability

Discuss
Answer: (a).it is assumed that each amino acid position is equally mutable
Q97.
The more conserved amino acids in similar proteins from different species are ones that play an essential role in structure and function and the less conserved are in sites that can vary without having a significant effect on function.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q98.
A gap opening penalty for any gap (g) and a gap extension penalty for each element in the gap (r) are most often used, to give a total gap score wx, according to the equation ______

a.

wx – rx = -g

b.

wx = g – rx

c.

wx = g + rx

d.

wx + g + rx = 0

Discuss
Answer: (c).wx = g + rx
Q99.
In the GCG and FASTA program suites, the scoring matrix itself is formatted in a way that includes default ______

a.

gap additions

b.

alignment scores

c.

score penalties

d.

gap penalties

Discuss
Answer: (d).gap penalties
Q100.
In case of the varying alignment, penalizing gaps heavily might occur. Then the best scoring local alignment between the sequences will be one that optimizes the score between matches and mismatches, without any gaps.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
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