DNA Replication MCQs

Welcome to our comprehensive collection of Multiple Choice Questions (MCQs) on DNA Replication, a fundamental topic in the field of Cytogenetics. Whether you're preparing for competitive exams, honing your problem-solving skills, or simply looking to enhance your abilities in this field, our DNA Replication MCQs are designed to help you grasp the core concepts and excel in solving problems.

In this section, you'll find a wide range of DNA Replication mcq questions that explore various aspects of DNA Replication problems. Each MCQ is crafted to challenge your understanding of DNA Replication principles, enabling you to refine your problem-solving techniques. Whether you're a student aiming to ace Cytogenetics tests, a job seeker preparing for interviews, or someone simply interested in sharpening their skills, our DNA Replication MCQs are your pathway to success in mastering this essential Cytogenetics topic.

Note: Each of the following question comes with multiple answer choices. Select the most appropriate option and test your understanding of DNA Replication. You can click on an option to test your knowledge before viewing the solution for a MCQ. Happy learning!

So, are you ready to put your DNA Replication knowledge to the test? Let's get started with our carefully curated MCQs!

DNA Replication MCQs | Page 2 of 4

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Q11.
Rolling circle mode of replication is ________

a.

Conservative

b.

Non Conservative

c.

Semi – Conservative

d.

Dispersed

Discuss
Answer: (c).Semi – Conservative
Q12.
What constitutes Primosome?

a.

Dna a, Dna b, Dna c, Dna G

b.

Dna b, Dna G

c.

Dna c, Dna b

d.

Dna a, Dna c

Discuss
Answer: (b).Dna b, Dna G
Q13.
If we mutate the DNA ligase and observe the length of the replicated strands in different time slots after replication initiation, what will we observe?

a.

The DNA will gradually increase in length till it is fully replicated

b.

Small fragments of DNA will be obtained increasing in number with time

c.

Mixture of small and long Fragments of definite length from the start whose concentration simply increases with time

d.

At first small fragment, then two separate bands showing long fragment with increasing length and short fragments of definite length.

Discuss
Answer: (d).At first small fragment, then two separate bands showing long fragment with increasing length and short fragments of definite length.
Q14.
If we mutate the DNA ligase and observe the length of the replicated strands in different time slots after replication initiation, what will we observe?

a.

Bacteria under viral attack don’t replicate

b.

Viral polymerase binds to it and thus can’t perform its function

c.

Virus uses it in a polymerization

d.

Cellular mechanism deactivates it

Discuss
Answer: (c).Virus uses it in a polymerization
Q15.
DNA replication in the two strands proceed in opposite direction as they are aligned oppositely with respect to 3’ and 5’ ends
( 5’——————————-3’
3’——————————-5’).

In this context which of the following is true.

a.

The two arms of the DNA Pol are exactly same with same orientation

b.

The two arms of the DNA Pol are exactly same with opposite orientation

c.

The two arms of the DNA Pol have different catalytic mechanism i.e. one polymerizes 3’ -> 5’ other 5’ -> 3’

d.

The two arms are isomers i.e. they have different arrangement of the subunits.

Discuss
Answer: (a).The two arms of the DNA Pol are exactly same with same orientation
Q16.
In case of eukaryotes replication initiates at ________

a.

TATA

b.

CpG islets

c.

AUG

d.

ARS

Discuss
Answer: (d).ARS
Q17.
Here are names of some factors necessary for prokaryotic replication. Which of these or their homologue is unnecessary for eukaryotes?

a.

Dna G

b.

Dna b

c.

Beta clamp

d.

SSB

Discuss
Answer: (a).Dna G
Q18.
You wanted to find out the importance of the DNA polymerases. So, you mutated the polymerases one by one and checked for survival. In which of these mutant cases will you see least survival rate?

a.

Alpha

b.

Beta

c.

Delta

d.

Eta

Discuss
Answer: (a).Alpha
Q19.
You design a circular ssDNA with a labeled RNA primer (alpha-P³² labeling). You add polymerase epsilon and required enzymes for replication to the fragment. What will you expect to see on autoradiography after gel electrophoresis?

a.

Single labeled band with some labeling at the bottom region

b.

Two labeled band one much lower than the other with labeling at the bottom region

c.

No band but labeling at the bottom

d.

Two labeled band one much lower than the other with no labeling at the bottom

Discuss
Answer: (d).Two labeled band one much lower than the other with no labeling at the bottom
Q20.
You design a plasmid with a gene for Histidine synthesis and a fragment containing ARS. You introduce it yeast culture and try to grow then in Histidine deficit media. What will be your observation?

a.

No growth

b.

One or two colonies

c.

Rapid growth with many colonies

d.

Normal growth with countable colonies

Discuss
Answer: (c).Rapid growth with many colonies
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