Gene and Promoter Prediction MCQs

Welcome to our comprehensive collection of Multiple Choice Questions (MCQs) on Gene and Promoter Prediction, a fundamental topic in the field of Bioinformatics. Whether you're preparing for competitive exams, honing your problem-solving skills, or simply looking to enhance your abilities in this field, our Gene and Promoter Prediction MCQs are designed to help you grasp the core concepts and excel in solving problems.

In this section, you'll find a wide range of Gene and Promoter Prediction mcq questions that explore various aspects of Gene and Promoter Prediction problems. Each MCQ is crafted to challenge your understanding of Gene and Promoter Prediction principles, enabling you to refine your problem-solving techniques. Whether you're a student aiming to ace Bioinformatics tests, a job seeker preparing for interviews, or someone simply interested in sharpening their skills, our Gene and Promoter Prediction MCQs are your pathway to success in mastering this essential Bioinformatics topic.

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Gene and Promoter Prediction MCQs | Page 4 of 9

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Q31.
Which of the following is untrue about FGENES?

a.

It stands for FindGenes

b.

It is a web-based program that uses LDA

c.

It is used to determine whether a signal is an exon

d.

It does not make a use of HMMs

Discuss
Answer: (d).It does not make a use of HMMs
Q32.
GENSCAN is awebbased program that makes predictions based on fifth-order HMMs.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q33.
Which of the following wrong about HMM GENE?

a.

It is also an HMM-based web program

b.

It uses a criterion called the conditional maximum likelihood to discriminate coding from non-coding features

c.

HMM prediction is unbiased toward the locked region

d.

If a sequence already has a sub-region identified as coding region, which may be based on similarity with cDNAs or proteins in a database, these regions are locked as coding regions

Discuss
Answer: (c).HMM prediction is unbiased toward the locked region
Q34.
Which of the following is untrue about Homology-Based Programs?

a.

They are based on the fact that exon structures and exon sequences of related species are less conserved

b.

This approach assumes that the database sequences are correct

c.

It is a reasonable assumption in light of the fact that many homologous sequences to be compared with are derived from cDNA or expressed sequence tags (ESTs) of the same species

d.

Potential coding frames in a query sequence are translated and used to align with closest protein homologs found in databases

Discuss
Answer: (a).They are based on the fact that exon structures and exon sequences of related species are less conserved
Q35.
The drawback of Homology-based approach is its reliance on the presence of homologs in databases.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q36.
GenomeScan is a web-based server that combines GENSCAN prediction results with BLASTX similarity searches.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q37.
Which of the following is untrue about EST2Genome?

a.

It is a web-based program purely based on the sequence alignment approach to define intron–exon boundaries

b.

It compares an EST (or cDNA) sequence with a genomic DNA sequence containing the corresponding gene

c.

The alignment is rarely done using a dynamic programming–based algorithm

d.

Advantage of the approach is the ability to find very small exons and alternatively spliced exons that are very difficult to predict by any ab initio–type algorithms

Discuss
Answer: (c).The alignment is rarely done using a dynamic programming–based algorithm
Q38.
Which of the following is untrue about SGP-1?

a.

The program translates all potential exons in each sequence and does pair wise alignment for the translated protein sequences using a dynamic programming approach

b.

The near-perfect matches at the protein level define coding regions

c.

It is a similarity-based web program that aligns two genomic DNA sequences from distinctly related organisms

d.

It stands for Syntenic Gene Prediction

Discuss
Answer: (c).It is a similarity-based web program that aligns two genomic DNA sequences from distinctly related organisms
Q39.
TwinScan is also a similarity-based gene-finding Server and it is similar to GenomeScan in that it uses GenScan to predict all possible exons from the genomic sequence.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q40.
Because different prediction programs have different levels of sensitivity and specificity, it makes sense to combine results of multiple programs based on consensus. This idea has prompted development of consensus-based algorithms.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
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