DNA and Genomic Sequencing MCQs

Welcome to our comprehensive collection of Multiple Choice Questions (MCQs) on DNA and Genomic Sequencing, a fundamental topic in the field of Bioinformatics. Whether you're preparing for competitive exams, honing your problem-solving skills, or simply looking to enhance your abilities in this field, our DNA and Genomic Sequencing MCQs are designed to help you grasp the core concepts and excel in solving problems.

In this section, you'll find a wide range of DNA and Genomic Sequencing mcq questions that explore various aspects of DNA and Genomic Sequencing problems. Each MCQ is crafted to challenge your understanding of DNA and Genomic Sequencing principles, enabling you to refine your problem-solving techniques. Whether you're a student aiming to ace Bioinformatics tests, a job seeker preparing for interviews, or someone simply interested in sharpening their skills, our DNA and Genomic Sequencing MCQs are your pathway to success in mastering this essential Bioinformatics topic.

Note: Each of the following question comes with multiple answer choices. Select the most appropriate option and test your understanding of DNA and Genomic Sequencing. You can click on an option to test your knowledge before viewing the solution for a MCQ. Happy learning!

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DNA and Genomic Sequencing MCQs | Page 15 of 17

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Q141.
Other functional classification schemes for genes include a broader category for genes involved in the same biological process, e.g., a three-group scheme for energy-related, information-related, and communication-related genes has also been used.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q142.
Two species that have recently diverged from a common ancestor might be expected to have a ________ set of genes and ________ chromosomes with these genes positioned along the chromosomes in the same order.

a.

distinct, similar

b.

similar, distinct

c.

similar, dissimilar

d.

similar, similar

Discuss
Answer: (d).similar, similar
Q143.
Which of the given statement is incorrect about the observations made with regard to gene order?

a.

Order is highly conserved in closely related species

b.

Order in closely related species becomes changed by rearrangements over evolutionary time

c.

As more and more rearrangements occur, there will no longer be any correspondence in the order of orthologous genes on the chromosome of one organism with that of a second organism

d.

Order is less conserved in closely related species

Discuss
Answer: (d).Order is less conserved in closely related species
Q144.
Which of the given statement is incorrect about the Chromosomal Rearrangements?

a.

Comparison of the number of rearrangements in a given period of evolutionary history may vary significantly from one organism to the next

b.

If gene A has a neighboring gene B, then if an ortholog of A occurs in another genome, there is an increased probability of an ortholog of B also occurring in the other organism

c.

If gene A has a neighboring gene B, then if an ortholog of A occurs in another genome, the B ortholog is more likely to be a neighbor of the A ortholog of the genome of the second species if the two species are more divergent

d.

In general, the order of orthologs is not well conserved in prokaryotes when the genomes have diverged sufficiently that the orthologs have < 50% identity

Discuss
Answer: (c).If gene A has a neighboring gene B, then if an ortholog of A occurs in another genome, the B ortholog is more likely to be a neighbor of the A ortholog of the genome of the second species if the two species are more divergent
Q145.
Which of the given statement is incorrect?

a.

In a given organism or species, genes are found in a given order that is maintained on the chromosomes from one generation to the next

b.

Genes with a related function are frequently found to be distorted on a chromosome

c.

A possibility is that there is genetic variation (alleles) within each gene in a cluster of a given species and that only certain allelic combinations of different genes are compatible

d.

Clustering of related genes presumably provides an evolutionary advantage to a species

Discuss
Answer: (b).Genes with a related function are frequently found to be distorted on a chromosome
Q146.
Which of the given statements is incorrect about global gene regulation?

a.

One way to obtain useful information about a genome is to determine which genes are induced or repressed in response to a phase of the cell cycle

b.

Sets of a gene whose expression rises and falls under the same condition are likely to have a related function

c.

Sets of a gene whose expression rises and falls under the same condition are likely to have dissimilar functions

d.

Cell cycle is a developmental phase, or a response to the environment

Discuss
Answer: (c).Sets of a gene whose expression rises and falls under the same condition are likely to have dissimilar functions
Q147.
Which of the given statements is incorrect about Microarray (or microchip) analysis?

a.

It is a new technology in which all of the genes of an organism are represented by oligonucleotide sequences spread out in an 80 x 80 array on microscope slides

b.

The oligonucleotide sequences cannot be synthesized directly on the slide

c.

The oligonucleotides are collectively hybridized to a labeled cDNA library prepared by reverse-transcribing mRNA from cells

d.

The amount of label binding to each oligonucleotide spot reflects the amount of mRNA in the cell

Discuss
Answer: (b).The oligonucleotide sequences cannot be synthesized directly on the slide
Q148.
Once a set of genes that are co-regulated has been found, the promoter regions of these genes may be analyzed for conserved patterns that represent sites of interaction with specific transcription factors.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q149.
Which of the given statements is incorrect about Microarray Analysis?

a.

It is designed to detect global changes in transcription in a genome

b.

It provides information about the levels of protein products of the genes

c.

The proteins are first separated in a column on the basis of size and then across a second dimension on a slab on the basis of charge

d.

Labeled protein samples may also be extracted from treated cells and separated by two-dimensional gel electrophoresis

Discuss
Answer: (b).It provides information about the levels of protein products of the genes
Q150.
In cluster analysis of microarray data– If Xi is the log odds value for gene X at time i, then for two genes X and Y and N observations, a similarity score is calculated. S(X,Y) is also known as the Pearson correlation coefficent. Xoffset and Yoffset can be the mean of the observations on X or Y, respectively, in which case is the standard deviation, or else Xoffset and Yoffset can be set to zero when a reference state is used. Which of the following best represents it?

a.

S(X,Y) = \(\frac{1}{N-2}\) βˆ‘i=1,N . (Xi – Xoffset) (Yi + Yoffset)/Ο•xQY

b.

S(X,Y) = \(\frac{1}{N}\) βˆ‘i=1,N . (Xi – Xoffset) (Yi – Yoffset)/Ο•xQY

c.

S(X,Y) = \(\frac{1}{N-1}\) βˆ‘i=1,N . (Xi + Xoffset) (Yi + Yoffset)/Ο•xQY

d.

S(X,Y) = \(\frac{1}{N}\) βˆ‘i=1,N+2 . (Xi + Xoffset) (Yi – Yoffset)/Ο•xQY

Discuss
Answer: (b).S(X,Y) = \(\frac{1}{N}\) βˆ‘i=1,N . (Xi – Xoffset) (Yi – Yoffset)/Ο•xQY
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