DNA and Genomic Sequencing MCQs

Welcome to our comprehensive collection of Multiple Choice Questions (MCQs) on DNA and Genomic Sequencing, a fundamental topic in the field of Bioinformatics. Whether you're preparing for competitive exams, honing your problem-solving skills, or simply looking to enhance your abilities in this field, our DNA and Genomic Sequencing MCQs are designed to help you grasp the core concepts and excel in solving problems.

In this section, you'll find a wide range of DNA and Genomic Sequencing mcq questions that explore various aspects of DNA and Genomic Sequencing problems. Each MCQ is crafted to challenge your understanding of DNA and Genomic Sequencing principles, enabling you to refine your problem-solving techniques. Whether you're a student aiming to ace Bioinformatics tests, a job seeker preparing for interviews, or someone simply interested in sharpening their skills, our DNA and Genomic Sequencing MCQs are your pathway to success in mastering this essential Bioinformatics topic.

Note: Each of the following question comes with multiple answer choices. Select the most appropriate option and test your understanding of DNA and Genomic Sequencing. You can click on an option to test your knowledge before viewing the solution for a MCQ. Happy learning!

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DNA and Genomic Sequencing MCQs | Page 16 of 17

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Q151.
In cluster analysis of microarray data– A node is created between the _________ scoring pair, and the gene expressed profiles of these two genes are averaged and the joined elements are weighted by the _________ of elements they contain.

a.

lowest, frequency

b.

average, sequence

c.

lowest, number

d.

highest, number

Discuss
Answer: (d).highest, number
Q152.
In cluster analysis of microarray data– For n genes, the process is repeated ________ times until a single element remains.

a.

n²

b.

n

c.

n¯¹

d.

n¯⁴

Discuss
Answer: (c).n¯¹
Q153.
The hierarchical clustering method generates a similarity score [S(X,Y)] for all gene combinations, places the scores in a matrix, joins those genes that have the highest score, and then continues to join progressively less similar pairs.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q154.
In Self-organizing maps a choice is made of a number of clusters by which to organize the data.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q155.
SVMs (Support vector machines) are a binary classification method to discriminate one set of data points from another.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q156.
In SVMs (Support vector machines) Data points are log-transformed and normalized as in method A, where for N observations of a gene i, the log transform Xi of the expression level Ei and reference level Ri is?

a.

Xi = \(\frac{Log (E_i/R_i)}{\sqrt{\sum_{j=1,N} Log_{z-2} (E_j/R_j)}}\)

b.

Xj = \(\frac{Log (E_j/R_i)}{\sqrt{\sum_{j=1,N} Log_z (E_j/R_j)}}\)

c.

Xi = \(\frac{Log (E_i/R_i)}{\sqrt{\sum_{j=1,(N-1)} Log_z (E_j/R_j)}}\)

d.

Xi = \(\frac{Log (E_i/R_i)}{\sqrt{\sum_{j=1,N} Log_z (E_j/R_j)}}\)

Discuss
Answer: (a).Xi = \(\frac{Log (E_i/R_i)}{\sqrt{\sum_{j=1,N} Log_{z-2} (E_j/R_j)}}\)
Q157.
When two proteins share a considerable degree of sequence identity throughout the sequence alignment, they are least likely to share the same function.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (b).False
Q158.
Other types of evidence for a relationship between two genes are also given that are not dependent in sequence similarity. Which of the following is a wrong statement?

a.

genes are closely linked on the same chromosomes

b.

genes are transcribed from the same DNA strand

c.

gene fusions are observed between otherwise separate genes

d.

phylogenetic profiles show the genes are not that commonly present in organisms

Discuss
Answer: (d).phylogenetic profiles show the genes are not that commonly present in organisms
Q159.
In Genome-wide prediction of protein functions by a combinatorial method– Each point represents a protein, and branches between proteins indicate a relationship by one of several criteria indicated in the legend.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q160.
Which of the given statement is untrue about functional genomics?

a.

Known functions are derived from experimental evidence in molecular biology and genetic studies with model organisms

b.

Non-Orthologous genes between biologically distinct species can be identified, and it is strong evidence for a related function

c.

Sequence-based methods of gene prediction can be augmented by the types of genome comparisons that are designed to identify related genes based on common patterns of expression, evolutionary profiles, chromosomal locations, and other features

d.

Genome analysis depends to a large extent on sequence analysis methods that identify gene function based on similarity between proteins of unknown function and proteins of known function

Discuss
Answer: (b).Non-Orthologous genes between biologically distinct species can be identified, and it is strong evidence for a related function
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