Structural Bioinformatics MCQs

Welcome to our comprehensive collection of Multiple Choice Questions (MCQs) on Structural Bioinformatics, a fundamental topic in the field of Bioinformatics. Whether you're preparing for competitive exams, honing your problem-solving skills, or simply looking to enhance your abilities in this field, our Structural Bioinformatics MCQs are designed to help you grasp the core concepts and excel in solving problems.

In this section, you'll find a wide range of Structural Bioinformatics mcq questions that explore various aspects of Structural Bioinformatics problems. Each MCQ is crafted to challenge your understanding of Structural Bioinformatics principles, enabling you to refine your problem-solving techniques. Whether you're a student aiming to ace Bioinformatics tests, a job seeker preparing for interviews, or someone simply interested in sharpening their skills, our Structural Bioinformatics MCQs are your pathway to success in mastering this essential Bioinformatics topic.

Note: Each of the following question comes with multiple answer choices. Select the most appropriate option and test your understanding of Structural Bioinformatics. You can click on an option to test your knowledge before viewing the solution for a MCQ. Happy learning!

So, are you ready to put your Structural Bioinformatics knowledge to the test? Let's get started with our carefully curated MCQs!

Structural Bioinformatics MCQs | Page 10 of 10

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Q91.
There are a large number of protein folds available, compared to millions of protein sequences.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (b).False
Q92.
Threading or structural fold recognition predicts the structural fold of an unknown protein sequence by fitting the sequence into a structural database and selecting the best-fitting fold.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q93.
The algorithms used here can be classified into two categories, pairwise energy based and profile based.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q94.
In the pairwise energy based method, a protein sequence is searched for in a structural fold database to find the best matching structural fold using ______ criteria.

a.

sequence-based

b.

structure-based

c.

energy-based

d.

residue-based

Discuss
Answer: (c).energy-based
Q95.
The next step in the pairwise energy based method is to build a crude model for the target sequence by replacing aligned residues in the template structure with the corresponding residues in the query.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q96.
Which of the following is untrue about profile method?

a.

A profile is constructed for a group of related protein structures

b.

The propensity of amino acids in not in picture of this method

c.

Statistical information from these aligned residues is then used to construct a profile

d.

The structural profile is generated by the superimposition of the structures to expose corresponding residues

Discuss
Answer: (b).The propensity of amino acids in not in picture of this method
Q97.
Because threading and fold recognition detect structural homologs ________ relying on sequence similarities, they have been shown to be _______ than PSI-BLAST in finding distant evolutionary relationships

a.

without completely, far more sensitive

b.

completely, far more sensitive

c.

completely, less sensitive

d.

without completely, less sensitive

Discuss
Answer: (a).without completely, far more sensitive
Q98.
Which of the following is untrue about threading and fold recognition?

a.

It assess the compatibility of an amino acid sequence with a known structure in a fold library

b.

If the protein fold to be predicted does not exist in the fold library, the method won’t necessarily fail

c.

If the protein fold to be predicted does not exist in the fold library, the method will fail

d.

Threading and fold recognition do not generate fully refined atomic models for the query sequences

Discuss
Answer: (b).If the protein fold to be predicted does not exist in the fold library, the method won’t necessarily fail
Q99.
Which of the following is untrue about 3D-PSSM?

a.

It is a web-based program that employs the structural profile method to identify protein folds

b.

The profiles for each protein superfamily are constructed by combining multiple smaller profiles

c.

A protein structural superfamily doesn’t have sequence-based PSI-BLAST profile

d.

In initial steps, protein structures in a superfamily based on the SCOP classification are superimposed

Discuss
Answer: (c).A protein structural superfamily doesn’t have sequence-based PSI-BLAST profile
Q100.
Which of the following is true about Gen Threader?

a.

It is a web-based program that uses a hybrid of the profile and pairwise energy methods

b.

It is a web-based program that uses profile methods only

c.

It is a web-based program that uses pairwise energy methods only

d.

The initial step is quite dissimilar to 3D-PSSM

Discuss
Answer: (a).It is a web-based program that uses a hybrid of the profile and pairwise energy methods
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