Structural Bioinformatics MCQs

Welcome to our comprehensive collection of Multiple Choice Questions (MCQs) on Structural Bioinformatics, a fundamental topic in the field of Bioinformatics. Whether you're preparing for competitive exams, honing your problem-solving skills, or simply looking to enhance your abilities in this field, our Structural Bioinformatics MCQs are designed to help you grasp the core concepts and excel in solving problems.

In this section, you'll find a wide range of Structural Bioinformatics mcq questions that explore various aspects of Structural Bioinformatics problems. Each MCQ is crafted to challenge your understanding of Structural Bioinformatics principles, enabling you to refine your problem-solving techniques. Whether you're a student aiming to ace Bioinformatics tests, a job seeker preparing for interviews, or someone simply interested in sharpening their skills, our Structural Bioinformatics MCQs are your pathway to success in mastering this essential Bioinformatics topic.

Note: Each of the following question comes with multiple answer choices. Select the most appropriate option and test your understanding of Structural Bioinformatics. You can click on an option to test your knowledge before viewing the solution for a MCQ. Happy learning!

So, are you ready to put your Structural Bioinformatics knowledge to the test? Let's get started with our carefully curated MCQs!

Structural Bioinformatics MCQs | Page 6 of 10

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Q51.
Which of the following is untrue regarding Chou–Fasman and GOR methods?

a.

Both are the first-generation methods

b.

They are developed in the 1970s

c.

They suffer from the fact that the prediction rules are somewhat arbitrary

d.

They are based on single sequence statistics with clear relation to known protein-folding theories

Discuss
Answer: (d).They are based on single sequence statistics with clear relation to known protein-folding theories
Q52.
Which of the following is untrue regarding Homology-Based Methods?

a.

The third generation of algorithms was developed in the late 1990s

b.

They were developed by making use of evolutionary information

c.

This type of method uses the ab initio secondary structure prediction of individual sequences only

d.

This type of method combines the ab initio secondary structure prediction of individual sequences and alignment information from multiple homologous sequences (>35% identity)

Discuss
Answer: (c).This type of method uses the ab initio secondary structure prediction of individual sequences only
Q53.
Because residues in the same aligned position are assumed to have the same secondary structure, any inconsistencies or errors in prediction of individual sequences can be corrected using a majority rule.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q54.
Which of the following is untrue regarding Prediction with Neural Networks?

a.

The third-generation prediction algorithms extensively apply sophisticated neural networks

b.

It is used to analyze substitution patterns in multiple sequence alignments

c.

It is not a machine learning process

d.

It requires a structure of multiple layers of interconnected variables or nodes

Discuss
Answer: (c).It is not a machine learning process
Q55.
Which of the following is untrue regarding Prediction with Neural Networks?

a.

It has to be first trained by sequences with known structures

b.

Between input and output are many connected hidden layers

c.

Between the connected hidden layers the machine learning takes place to adjust the mathematical weights of internal connections

d.

It doesn’t have to be first trained by sequences with known structures

Discuss
Answer: (d).It doesn’t have to be first trained by sequences with known structures
Q56.
Which of the following is untrue regarding Prediction with Neural Networks?

a.

When multiple sequence alignments and neural networks are combined, the result is further improved accuracy

b.

A neural network is trained by a single sequence

c.

A neural network is trained by a sequence profile derived from the multiple sequence alignment

d.

When the sufficiently trained network processes an unknown sequence, it applies the rules learned in training to recognize particular structural patterns

Discuss
Answer: (b).A neural network is trained by a single sequence
Q57.
Which of the following is untrue regarding PHD?

a.

It stands for Profile network from Heidelberg

b.

It is a web-based program that combines neural network only

c.

It first performs a BLASTP of the query sequence against a non redundant protein sequence database

d.

In initial steps it finds a set of homologous sequences, which are aligned with the MAXHOM program (a weighted dynamic programming algorithm performing global alignment)

Discuss
Answer: (b).It is a web-based program that combines neural network only
Q58.
Which of the following is untrue regarding the transmembrane proteins?

a.

Constitute up to 30% of all cellular proteins

b.

They are responsible for performing a wide variety of important functions in a cell, such as signal transduction, cross-membrane transport, and energy conversion

c.

The membrane proteins are also of tremendous biomedical importance

d.

They are not drug targets or receptors

Discuss
Answer: (d).They are not drug targets or receptors
Q59.
The structures of this group of proteins, however, are comparatively a lot difficult to resolve either by x-ray crystallography or nuclear magnetic resonance (NMR) spectroscopy.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q60.
Which of the following is untrue regarding Prediction of Helical Membrane Proteins?

a.

For membrane proteins consisting of transmembrane α–helices, these transmembrane helices are predominantly hydrophobic with a specific distribution of positively charged residues

b.

The α-helices generally run perpendicular to the membrane plane

c.

The α-helices generally run parallel to the membrane plane

d.

The α-helices have an average length between seventeen and twenty-five residues

Discuss
Answer: (c).The α-helices generally run parallel to the membrane plane
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