Structural Bioinformatics MCQs

Welcome to our comprehensive collection of Multiple Choice Questions (MCQs) on Structural Bioinformatics, a fundamental topic in the field of Bioinformatics. Whether you're preparing for competitive exams, honing your problem-solving skills, or simply looking to enhance your abilities in this field, our Structural Bioinformatics MCQs are designed to help you grasp the core concepts and excel in solving problems.

In this section, you'll find a wide range of Structural Bioinformatics mcq questions that explore various aspects of Structural Bioinformatics problems. Each MCQ is crafted to challenge your understanding of Structural Bioinformatics principles, enabling you to refine your problem-solving techniques. Whether you're a student aiming to ace Bioinformatics tests, a job seeker preparing for interviews, or someone simply interested in sharpening their skills, our Structural Bioinformatics MCQs are your pathway to success in mastering this essential Bioinformatics topic.

Note: Each of the following question comes with multiple answer choices. Select the most appropriate option and test your understanding of Structural Bioinformatics. You can click on an option to test your knowledge before viewing the solution for a MCQ. Happy learning!

So, are you ready to put your Structural Bioinformatics knowledge to the test? Let's get started with our carefully curated MCQs!

Structural Bioinformatics MCQs | Page 8 of 10

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Q71.
In Multicoil, The scoring matrix is constructed based on a database of known three-stranded coiled coils only.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (b).False
Q72.
Leucine zipper domains are a special type of coiled coils found in transcription regulatory proteins which contain two anti parallel α-helices held together by hydrophobic interactions of leucine residues.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q73.
Which of the following is untrue regarding PSIPRED?

a.

It is a web-based program that predicts protein secondary structures

b.

It uses a combination of evolutionary information and neural networks

c.

It uses a combination of evolutionary information only

d.

The multiple sequence alignment is derived from a PSI-BLAST database search

Discuss
Answer: (c).It uses a combination of evolutionary information only
Q74.
Prof is not similar to PHD.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (b).False
Q75.
Jpred combines the analysis results from six prediction algorithms, including PHD, PREDATOR, DSC, NNSSP, Jnet, and ZPred.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q76.
Which of the following is untrue about homology modeling?

a.

Homology modeling predicts protein structures based on sequence homology with known structures

b.

It is also known as comparative modeling

c.

The principle behind it is that if two proteins share a high enough sequence similarity, they are likely to have very similar three-dimensional structures

d.

It doesn’t involve the evolutionary distances anywhere

Discuss
Answer: (d).It doesn’t involve the evolutionary distances anywhere
Q77.
Which of the following is untrue about template Selection Step?

a.

The first step in protein structural modeling is to select appropriate structural templates

b.

This forms the foundation for rest of the modeling process

c.

There is no use of heuristic alignment search programs

d.

The template selection involves searching the Protein Data Bank (PDB) for homologous proteins with determined structures

Discuss
Answer: (c).There is no use of heuristic alignment search programs
Q78.
Which of the following is untrue about Sequence Alignment Step?

a.

Once the structure with the highest sequence similarity is identified as a template, the full-length sequences of the template and target proteins need to be realigned using refined alignment algorithms to obtain optimal alignment

b.

The realignment is the most critical step in homology modeling

c.

The realignment directly affects the quality of the final model

d.

Errors made in the alignment step can be corrected in the following modeling steps

Discuss
Answer: (d).Errors made in the alignment step can be corrected in the following modeling steps
Q79.
Which of the following is untrue about Backbone Model Building Step?

a.

Once optimal alignment is achieved, residues in the aligned regions of the target protein can assume a similar structure as the template proteins

b.

Coordinates of the corresponding residues of the template proteins can be simply copied onto the target protein

c.

If the two residues differ, everything other than the backbone atoms can be copied

d.

If the two aligned residues are identical, coordinates of the side chain atoms are copied along with the main chain atoms

Discuss
Answer: (c).If the two residues differ, everything other than the backbone atoms can be copied
Q80.
Which of the following is untrue about Loop Modeling Step?

a.

In the sequence alignment for modeling, there are often regions caused by insertions and deletions producing gaps in sequence alignment

b.

In the sequence alignment for modeling, there are no regions producing gaps in sequence alignment

c.

The gaps cannot be directly modeled

d.

Loop modeling is required for closing the gaps requires

Discuss
Answer: (b).In the sequence alignment for modeling, there are no regions producing gaps in sequence alignment
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