Genomics and Proteomics MCQs

Welcome to our comprehensive collection of Multiple Choice Questions (MCQs) on Genomics and Proteomics, a fundamental topic in the field of Bioinformatics. Whether you're preparing for competitive exams, honing your problem-solving skills, or simply looking to enhance your abilities in this field, our Genomics and Proteomics MCQs are designed to help you grasp the core concepts and excel in solving problems.

In this section, you'll find a wide range of Genomics and Proteomics mcq questions that explore various aspects of Genomics and Proteomics problems. Each MCQ is crafted to challenge your understanding of Genomics and Proteomics principles, enabling you to refine your problem-solving techniques. Whether you're a student aiming to ace Bioinformatics tests, a job seeker preparing for interviews, or someone simply interested in sharpening their skills, our Genomics and Proteomics MCQs are your pathway to success in mastering this essential Bioinformatics topic.

Note: Each of the following question comes with multiple answer choices. Select the most appropriate option and test your understanding of Genomics and Proteomics. You can click on an option to test your knowledge before viewing the solution for a MCQ. Happy learning!

So, are you ready to put your Genomics and Proteomics knowledge to the test? Let's get started with our carefully curated MCQs!

Genomics and Proteomics MCQs | Page 12 of 12

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Q111.
Which of the following is untrue regarding the classic yeast two-hybrid method?

a.

It is used for the detection of Protein interactions

b.

Method that relies on the interaction of “bait” and “prey” proteins in molecular constructs in yeast

c.

DNA-binding domain and a trans-activation domain don’t necessarily interact

d.

In this strategy, a two-domain transcriptional activator is employed as a helper for determining protein–protein interactions

Discuss
Answer: (c).DNA-binding domain and a trans-activation domain don’t necessarily interact
Q112.
If the bait and prey proteins _______ they bring the DNA-binding and trans-activation domains in such close proximity that they reconstitute the function of the transcription activator, turning ____ the expression of a reporter gene as a result. Which of the following is not the correct pair of blanks?

a.

physically interact, on

b.

do not interact, on

c.

do not interact, off

d.

stop interacting, off

Discuss
Answer: (b).do not interact, on
Q113.
Which of the following is untrue regarding the classic yeast two-hybrid method?

a.

Protein–protein interaction networks of yeast and a small number of other species have been subsequently determined using this method

b.

This technique is a high throughput approach

c.

Each bait and prey construct has to be prepared individually to map interactions between all proteins

d.

It has been systematically applied to study interactions at the whole proteome level

Discuss
Answer: (b).This technique is a high throughput approach
Q114.
An alternative approach to determining protein–protein interactions is to use a large-scale affinity purification technique that involves attaching fusion tags to proteins and purifying the associated protein complexes in an affinity chromatography column.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q115.
Which of the following is untrue regarding the Predicting Interactions Based on Domain Fusion?

a.

It is based on gene fusion events

b.

Predicting protein–protein interactions is called the “Rosetta stone” method

c.

A fused protein often reveals relationships between its domain components

d.

A fused protein doesn’t necessarily reveal about the relationships between its domain components

Discuss
Answer: (d).A fused protein doesn’t necessarily reveal about the relationships between its domain components
Q116.
When the two domains are located in two different proteins, to preserve the same functionality, their close proximity and interaction have to be preserved as well.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q117.
The justification behind Rosetta stone method is that when two domains are fused in a single protein, they have to be in _______ proximity to perform a common function.

a.

distant

b.

close

c.

extremely distant

d.

extremely close

Discuss
Answer: (d).extremely close
Q118.
In Predicting Interactions Based on Gene Neighbors if a certain gene linkage is found to be indeed conserved across divergent genomes, it can be used as a strong indicator of formation of an operon that encodes proteins that are functionally and even physically coupled.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q119.
Which of the following is untrue regarding the predicting Interactions Based on Phylogenetic Information?

a.

Proteins do not operate as a complex

b.

This method detects the co-presence or co-absence of orthologs across a number of genomes

c.

Protein interactions can be predicted using phylogenetic profiles

d.

Phylogenetic profile are defined as patterns of gene pairs that are concurrently present or absent across genomes

Discuss
Answer: (a).Proteins do not operate as a complex
Q120.
Which of the following is untrue regarding the STRING?

a.

Search Tool for the Retrieval of Interacting Genes/Proteins

b.

Functional associations include only the direct protein-protein interactions

c.

It is based on combined evidence of gene linkage, gene fusion and phylogenetic profiles

d.

It is a web server that predicts gene and protein functional associations

Discuss
Answer: (b).Functional associations include only the direct protein-protein interactions
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