Genomics and Proteomics MCQs

Welcome to our comprehensive collection of Multiple Choice Questions (MCQs) on Genomics and Proteomics, a fundamental topic in the field of Bioinformatics. Whether you're preparing for competitive exams, honing your problem-solving skills, or simply looking to enhance your abilities in this field, our Genomics and Proteomics MCQs are designed to help you grasp the core concepts and excel in solving problems.

In this section, you'll find a wide range of Genomics and Proteomics mcq questions that explore various aspects of Genomics and Proteomics problems. Each MCQ is crafted to challenge your understanding of Genomics and Proteomics principles, enabling you to refine your problem-solving techniques. Whether you're a student aiming to ace Bioinformatics tests, a job seeker preparing for interviews, or someone simply interested in sharpening their skills, our Genomics and Proteomics MCQs are your pathway to success in mastering this essential Bioinformatics topic.

Note: Each of the following question comes with multiple answer choices. Select the most appropriate option and test your understanding of Genomics and Proteomics. You can click on an option to test your knowledge before viewing the solution for a MCQ. Happy learning!

So, are you ready to put your Genomics and Proteomics knowledge to the test? Let's get started with our carefully curated MCQs!

Genomics and Proteomics MCQs | Page 9 of 12

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Q81.
The classic protein separation methods involve two-dimensional gel electrophoresis followed by gel image analysis.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q82.
Which of the following is incorrect regarding 2D-Page?

a.

It stands for Two-dimensional polyacrylamide gel electrophoresis

b.

It separates proteins by charge only

c.

The gel is run in one direction in a pH gradient under a non-denaturing condition

d.

It works to separate proteins by isoelectric points (pI)

Discuss
Answer: (b).It separates proteins by charge only
Q83.
Which of the following is incorrect regarding 2D-Page?

a.

Not all proteins can be separated by this method or stained properly

b.

The stained gel can be scanned and digitized for image analysis

c.

Membrane proteins are largely hydrophilic and readily solubilized

d.

One of the challenges of this technique is the separation of membrane proteins

Discuss
Answer: (c).Membrane proteins are largely hydrophilic and readily solubilized
Q84.
Comparing two-dimensional gel images from various experiments can sometimes pose a challenge because the gels, unlike DNA microarrays, may shrink or warp.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q85.
Which of the following is incorrect regarding Mass Spectrometry Protein Identification?

a.

The proteolysis doesn’t generate a pattern according to molecular weight

b.

Proteins can be identified and characterized using MS

c.

The proteins from a two dimensional gel system are first digested in situ with a protease

d.

Protein spots of interest are excised from the two-dimensional gel

Discuss
Answer: (a).The proteolysis doesn’t generate a pattern according to molecular weight
Q86.
Electrospray ionization MS and matrix-assisted laser desorption ionization (MALDI) MS only differ in the ionization procedure used.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q87.
Which of the following is incorrect regarding the Protein Identification through Database Searching?

a.

MS characterization of proteins is highly dependent on bioinformatic analysis

b.

Bioinformatics programs can be used to search for the identity of a protein in a database of theoretically digested proteins

c.

Even in reality, the protease digestion is always perfect in MS

d.

The purpose of the database search is to find exact or nearly exact matches

Discuss
Answer: (c).Even in reality, the protease digestion is always perfect in MS
Q88.
ExPASY is a comprehensive proteomics web server with a suite of programs for searching peptide information from the SWISS-PROT and TrEMBL databases.

a.

True

b.

False

c.

May be True or False

d.

Can't say

Discuss
Answer: (a).True
Q89.
Which of the following is incorrect regarding Mascot and ProFound?

a.

ProFound is a web server with a set of interconnected programs

b.

ProFound searches a protein sequence database using MS fingerprinting information

c.

Bayesian algorithm is not involved in ProFound

d.

Mascot is a web server that identifies proteins based on peptide mass fingerprints, sequence entries, or raw MS/MS data from one or more peptides

Discuss
Answer: (c).Bayesian algorithm is not involved in ProFound
Q90.
Which of the following is incorrect regarding Differential In-Gel Electrophoresis?

a.

Proteins are mixed together before electrophoresis on a two-dimensional gel

b.

Differentially expressed proteins in both conditions can’t be visualized in the same gel

c.

In this, Differences in protein expression patterns can be detected in a similar way as in fluorescent-labeled DNA microarrays

d.

Proteins from experimental and control samples are labeled with differently colored fluorescent dyes

Discuss
Answer: (b).Differentially expressed proteins in both conditions can’t be visualized in the same gel
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